3,9-bis((ethylthio)methyl)-K-252a

Product Name: 3,9-bis((ethylthio)methyl)-K-252a
CAS No.: 156177-65-0
Chemical Name: 3,9-bis((ethylthio)methyl)-K-252a
Synonyms: Kt7515;C106592;Cep1347;Kt-7515;Kt 7515;Cep-1347;Cep 1347;9-Bis(etsm)-K-252a;CEP-1347 (KT-7515;3,9-Bis(etsm)-K-252a
CBNumber: CB21381603
Molecular Formula: C33H33N3O5S2
Formula Weight: 615.76
MOL File: 156177-65-0.mol

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3,9-bis((ethylthio)methyl)-K-252a Property

Boiling point:: 786.8±60.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: <6.16mg/ml in DMSO
form: solid
pka: 11.94±0.40(Predicted)
color: Pale yellow

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Safety

HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4924
Product name: CEP1347
Purity: ≥97%(HPLC)
Packaging: 1
Price: $288
Updated: 2021/12/16

TRC

Product number: C256695
Product name: CEP1347
Packaging: 0.5mg
Price: $450
Updated: 2021/12/16

Usbiological

Product number: 254917
Product name: CEP 1347
Packaging: 1mg
Price: $603
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000067
Product name: CEP-1347
Purity: 95.00%
Packaging: 5MG
Price: $495.73
Updated: 2021/12/16

ApexBio Technology

Product number: B7720
Product name: CEP1347
Packaging: 1mg
Price: $417
Updated: 2021/12/16

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3,9-bis((ethylthio)methyl)-K-252a Chemical Properties,Usage,Production

Uses

CEP 1347 (cas# 156177-65-0) is a useful research chemical.CEP 1347 promotes neuronal survival in culture and in vivo.

Biological Activity

cep-1347, also called kt 7515, is an inhibitor of the c-jun n-terminal kinase (jnk) signaling pathway, with an ic50 value for jnk1 activation of 20 ± 2 nm in rat embryonic motoneurons [1].the jnk pathway, also known as the stress-activated protein kinase (sapk) pathway, is one of the signaling cascades that mediate the apoptotic death in response to a variety of stressful stimuli. jnk activation by phosphorylation is important for neuronal cell death after injury in vivo and after trophic factor withdrawal in vitro [2].cep-1347 induced neuronal survival. jnk1 activity in untreated cell cultures increased approximately fourfold within 24 hr after plating. as early as 15 min after the application of cep-1347 at 500 nm, the activity of jnk1 sharply decreased to ~50% of control levels. for the next 24 hr, the activity of jnk1 continued to decrease. cultures rich in motoneurons were grown in the presence of cep-1347 at increasing concentrations, and the ic50 for jnk1 activity at 22 hr was 21 ± 2 nm, whereas the ec50 for cell survival at 5 d was 20 ± 2 nm [1].cep-1347 can affect noise-induced hearing loss. data showed that hearing thresholds 2 d before noise exposure showed no significant difference between the noise-exposed control and treated group. hearing threshold shifts in all guinea pigs 2 d after the noise exposure. by day 6 after exposure, threshold shifts were significantly less in the cep-1347 group than in the noise-exposed control group. by 2 weeks after exposure, the difference between the two groups became more pronounced [2].

in vivo

CEP-1347 (0-60 mg/kg; Subcutaneous injection (s.c.)) in rats treated with Caerulein (HY-A0190) (10 μg/kg; Intravenous injection (i.v.)) can dose-dependent inhibit Caerulein Induced JNK activation and improve pancreatitis induced by pancreatin^[6].

Animal Model:	male white Sprague-Dawley rats^[6]
Dosage:	Caerulein (HY-A0190): 10 μg/kg; CEP-1347: 0-60 mg/kg
Administration:	Caerulein: Intravenous injection (i.v.); CEP-1347: Subcutaneous injection (s.c.)
Result:	Caerulein-induced JNK activation was dose-dependent inhibited.

IC 50

JNK1

storage

Store at -20°C

References

[1]. maroney ac, glicksman ma, basma an, et al. motoneuron apoptosis is blocked by cep-1347 (kt 7515), a novel inhibitor of the jnk signaling pathway[j]. the journal of neuroscience, 1998, 18(1): 104-111.
[2]. pirvola u, liang xq, virkkala j, et al. rescue of hearing, auditory hair cells, and neurons by cep-1347/kt7515, an inhibitor of c-jun n-terminal kinase activation[j]. the journal of neuroscience, 2000, 20(1): 43-50.

3,9-bis((ethylthio)methyl)-K-252a Preparation Products And Raw materials

Raw materials

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156177-65-0, 3,9-bis((ethylthio)methyl)-K-252aRelated Search:

K-252A K-252A

3,9-bis((ethylthio)methyl)-K-252a

3,9-Bis(etsm)-K-252a

C106592

Cep 1347

Cep1347

Cep-1347

Kt 7515

Kt7515

Kt-7515

SCMLRESZJCKCTC-KMYQRJGFSA-N

3;9-BIS(ETSM)-K-252A; CEP 1347; CEP-1347; CEP1347; KT 7515

9-Bis(etsm)-K-252a

(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester

CEP-1347 (KT-7515

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 5,16-bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid,5,16-bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-,methyl ester, (9S,10R,12

156177-65-0

C33H33N3O5S2