nitroflurbiprofen

Product Name: nitroflurbiprofen
CAS No.: 158836-71-6
Chemical Name: nitroflurbiprofen
Synonyms: HCT 1206;nitroflurbiprofen;Nitroxybutyl flurbiprofen;Nitroflurbiprofen, 10 mM in DMSO;Cyclooxygenase,Inhibitor,COX,Nitroflurbiprofen,HCT-1206,inhibit,HCT1206;[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester
CBNumber: CB21392461
Molecular Formula: C19H20FNO5
Formula Weight: 361.36
MOL File: 158836-71-6.mol

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nitroflurbiprofen Property

Boiling point:: 468.8±45.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6575
Product name: Nitroflurbiprofen
Purity: 99.64%
Packaging: 1mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-6575
Product name: Nitroflurbiprofen
Purity: 99.64%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0025712
Product name: HCT 1026
Purity: 95.00%
Packaging: 5MG
Price: $505.89
Updated: 2021/12/16

ChemScene

Product number: CS-6575
Product name: Nitroflurbiprofen
Purity: 99.64%
Packaging: 10mg
Price: $816
Updated: 2021/12/16

ChemScene

Product number: CS-6575
Product name: Nitroflurbiprofen
Purity: 99.64%
Packaging: 20mg
Price: $1440
Updated: 2021/12/16

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nitroflurbiprofen Chemical Properties,Usage,Production

Uses

Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.

Definition

ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2.

in vivo

In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors^[1].

IC 50

COX

References

[1] Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19. DOI:10.1053/j.gastro.2006.12.041

nitroflurbiprofen Preparation Products And Raw materials

Raw materials

Preparation Products

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nitroflurbiprofen Suppliers

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158836-71-6, nitroflurbiprofenRelated Search:

[1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER (2-FLUORO-4-BIPHENYL)ACETIC ACID ETHYL P-TOLYLACETATE alpha-Methyl-4-biphenylacetic acid 1-Butyl nitrite Flurbiprofen 3-Fluoro-4-methylphenylacetic acid nitroflurbiprofen N-BUTYL NITRATE METHYL 3-FLUOROPHENYLACETATE 4-Biphenylacetic acid 3-FLUORO-4-METHYLPHENETHYL ALCOHOL 3-Fluorophenylacetic acid felbinacethyl

nitroflurbiprofen

HCT 1206

Nitroxybutyl flurbiprofen

[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester

Cyclooxygenase,Inhibitor,COX,Nitroflurbiprofen,HCT-1206,inhibit,HCT1206

Nitroflurbiprofen, 10 mM in DMSO

158836-71-6

C19H20FNO5