3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol
- Product Name
- 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol
- CAS No.
- 124937-73-1
- Chemical Name
- 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol
- Synonyms
- Tolterodine int;Tolterodine EP Impurity A;Tolterodine Tartrate Impurity A;Tolterodine Tartrate EP Impurity A;BENZENEPROPANOL2-METHOXY-5-METHYL-Y-PHENYL;2-Methoxy-5-Methyl-y-phenylbenzenepropanol;2-Methoxy-5-methyl-γ-phenylbenzenepropanol;Benzenepropanol, 2-methoxy-5-methyl-γ-phenyl-;3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol;2-Methoxy-5-methyl-gamma-phenylbenzenepropanol
- CBNumber
- CB2185259
- Molecular Formula
- C17H20O2
- Formula Weight
- 256.34
- MOL File
- 124937-73-1.mol
3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol Property
- Boiling point:
- 413.8±33.0 °C(Predicted)
- Density
- 1.066±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.94±0.10(Predicted)
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C17H20O2/c1-13-8-9-17(19-2)16(12-13)15(10-11-18)14-6-4-3-5-7-14/h3-9,12,15,18H,10-11H2,1-2H3
- InChIKey
- OCGTUTJXBDQGKL-UHFFFAOYSA-N
- SMILES
- O(C)c1c(cc(cc1)C)C(CCO)c2ccccc2
- CAS DataBase Reference
- 124937-73-1(CAS DataBase Reference)
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0001699
- Product name
- Tolterodine impurity E
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 15 mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- Y0001699
- Product name
- Tolterodine impurity E
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001699
- Price
- $211
- Updated
- 2024/03/01
- Product number
- M264465
- Product name
- 2-Methoxy-5-methyl-γ-phenylbenzenepropanol
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- M264465
- Product name
- 2-Methoxy-5-methyl-γ-phenylbenzenepropanol
- Packaging
- 10g
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- 59785
- Product name
- 2-Methoxy-5-methyl-γ-phenylbenzenepropanol
- Packaging
- 1g
- Price
- $640
- Updated
- 2021/12/16
3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol Chemical Properties,Usage,Production
Uses
2-Methoxy-5-methyl-γ-phenylbenzenepropanol is a related compound to Tolterodine (T535795), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence.
Synthesis
109089-77-2
124937-73-1
General procedure for the synthesis of 3-(2-methoxy-5-methylphenyl)-3-phenylpropanol from 3-(2-methoxy-5-methylphenyl)-3-phenyl-1-propanol: Over a period of 2 hours, 0.5 kg of 3-(2-methoxy-5-methylphenyl)-3-phenylpropanoic acid dissolved in 2.0 L of tetrahydrofuran was added slowly and dropwise to 0.105 kg of sodium borohydride containing a 0.5 L of tetrahydrofuran suspension. After the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, 0.177 kg of methanesulfonic acid was slowly added over 1 hour. After addition, stirring was continued at room temperature for 1 hour. The reaction mixture was heated to 65-70°C and stirring was maintained for 8-10 hours. Upon completion of the reaction, it was cooled to 0-5 °C. The pH of the reaction mixture was adjusted to 2-3 with 0.25 L of aqueous 1 M hydrochloric acid, followed by extraction with ethyl acetate (1 L x 2). The organic layers were combined and washed sequentially with 2.0 L of water and 2.0 L of saturated saline. The solvent was removed by distillation under reduced pressure (30-40 mmHg) to give 3-(2-methoxy-5-methylphenyl)-3-phenyl-1-propanol (yield: 0.462 kg, 97% yield). The purity of the product was >95% by HPLC analysis.
References
[1] Patent: WO2010/46801, 2010, A2. Location in patent: Page/Page column 16
[2] Patent: WO2010/92500, 2010, A2. Location in patent: Paragraph 157-164
3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol manufacturers
- Product
- 3-(2-Methoxy-5-methylphenyl)-3-phenyl propanol 124937-73-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-23