ChemicalBook > CAS DataBase List > N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
- Product Name
- N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
- CAS No.
- 313480-47-6
- Chemical Name
- N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide
- Synonyms
- I S-1.76;IGS-1.76 ，E0936;IGS-1.76, 10 mM in DMSO;N-(Benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide;Benzenepropanamide, N-2-benzothiazolyl-β-phenyl-;N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide;NCS-1,Ric8a,IGS 1.76,PPI,inhibit,IGS1.76,IGS-1.76,Inhibitor
- CBNumber
- CB21893317
- Molecular Formula
- C22H18N2OS
- Formula Weight
- 358.46
- MOL File
- 313480-47-6.mol
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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (697.43 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Chemical Properties,Usage,Production
Uses
IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1].
Biological Activity
IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1]. IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1].
References
[1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14):5910-5921.
N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide Suppliers
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