2-Fluoro-N-methoxy-N-methylbenzamide
- Product Name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- CAS No.
- 198967-24-7
- Chemical Name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- Synonyms
- N-Methoxy-N-Methyl-2-fluorobenzaMide;2-Fluoro-N-methoxy-N-metylbenzamide ;2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE;Benzamide, 2-fluoro-N-methoxy-N-methyl-;FMMB 3-Fluoro-n-methoxy-n-methylbenzamide;2-Fluoro-N-methoxy its-N-methylbenzoyl Amine
- CBNumber
- CB2199861
- Molecular Formula
- C9H10FNO2
- Formula Weight
- 183.18
- MOL File
- 198967-24-7.mol
2-Fluoro-N-methoxy-N-methylbenzamide Property
- Boiling point:
- 299.9±23.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F593778
- Product name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F593778
- Product name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 0228AB
- Product name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- HCH0019969
- Product name
- 2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1334.03
- Updated
- 2021/12/16
- Product number
- A285446
- Product name
- 2-Fluoro-N-methoxy-N-methylbenzamide
- Purity
- 95%
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
2-Fluoro-N-methoxy-N-methylbenzamide Chemical Properties,Usage,Production
Synthesis
6638-79-5
393-52-2
198967-24-7
The general procedure for the synthesis of 2-fluoro-N-methoxy-N-methylbenzamide from dimethylhydroxylamine hydrochloride and o-fluorobenzoyl chloride was as follows: N,O-dimethylhydroxylamine hydrochloride (23.4 g, 240 mmol) was suspended in tetrahydrofuran (THF, 100 mL) and cooled to 0 °C under nitrogen protection. Pyridine (32 mL, 400 mmol) was added rapidly. A solution of o-fluorobenzoyl chloride (9.5 mL, 80 mmol) in THF (50 mL) was added dropwise over 15 minutes. The ice bath was removed and the reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, water (100 mL) and ethyl acetate (AcOEt, 100 mL) were added to separate the organic and aqueous phases. The aqueous phase was extracted again with ethyl acetate (100 mL). All organic phases were combined and washed sequentially with 1N hydrochloric acid (2 x 100 mL) and 1N sodium hydroxide (100 mL). The organic phase was dried with magnesium sulfate (MgSO4) and concentrated to give a yellow oil (10.7 g). The oily substance was purified by vacuum distillation and the colorless oily 2-fluoro-N-methoxy-N-methylbenzamide (9.1 g, 62% yield) distilled at 0.22 Torr, 57-59 °C was collected. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 3.34 (s, 3H), 3.54 (br, 3H), 7.10 (m, 1H), 7.19 (m, 1H), 7.42 (m, 2H).
References
[1] RSC Advances, 2013, vol. 3, # 26, p. 10158 - 10162
[2] Patent: WO2013/142038, 2013, A2. Location in patent: Paragraph 0130
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 21, p. 6974 - 6992
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1415 - 1419
[5] Patent: WO2006/3096, 2006, A1. Location in patent: Page/Page column 73
2-Fluoro-N-methoxy-N-methylbenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-Fluoro-N-methoxy-N-methylbenzamide Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- 15026594951
- Fax
- 0556-5030632
- rs@raise-chem.com
- Country
- China
- ProdList
- 4454
- Advantage
- 55
- Tel
- +1-510-219-6317
- Fax
- +1-650-486-1361
- sales@hbcchem.com
- Country
- United States
- ProdList
- 10648
- Advantage
- 60
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
View Lastest Price from 2-Fluoro-N-methoxy-N-methylbenzamide manufacturers
- Product
- 2-Fluoro-N-methoxy-N-methylbenzamide 198967-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200KG
- Release date
- 2019-08-30