2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

Product Name: 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V
CAS No.: 24418-86-8
Chemical Name: 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V
Synonyms: SKI V;SKI V, 10 mM in DMSO;Sphingosine Kinase Inhibitor V;2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one;2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one;3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-;(2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one;(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one;2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V;PI3K,SKI V,Inhibitor,Apoptosis,GST-hSK,sphingosine,second,mitogenic,Phosphoinositide 3-kinase,S1P,Sphingosine kinase,kinase,SphK,inhibit,antitumor,noncompetitive,messenger,non-lipid
CBNumber: CB22091422
Molecular Formula: C15H10O4
Formula Weight: 254.24
MOL File: 24418-86-8.mol

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2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Property

Boiling point:: 493.2±45.0 °C(Predicted)
Density: 1.489±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 250 mg/mL (983.32 mM)
pka: 8.99±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0012759
Product name: SKIV
Purity: 98.09%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0012759
Product name: SKIV
Purity: 98.09%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0012759
Product name: SKIV
Purity: 98.09%
Packaging: 50mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0012759
Product name: SKIV
Purity: 98.09%
Packaging: 100mg
Price: $1850
Updated: 2021/12/16

Arctom

Product number: AS712312
Product name: 2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
Purity: 98%
Packaging: 1mg
Price: $148
Updated: 2021/12/16

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2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Chemical Properties,Usage,Production

Uses

SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].

Definition

ChEBI: 3',4'-dihydroxyaurone is a hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxyaurone and a member of catechols. It is functionally related to a 2',3,4-trihydroxy-trans-chalcone.

Biological Activity

SKI V is a non-competitive, potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with IC50 of 2 μM against GST-hSK. SKI V potently inhibits PI3K with IC50 of 6 μM for hPI3k. SKI V reduces the formation of the mitotic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity.

in vivo

SKI V (75 mg/kg; ip; days 1, 5, 9, 15) significantly lowers tumor growth (>50% decreased at day 18) than control animals.

< td class="col2"> IP; days 1, 5, 9, 15

Animal Model:	6-8 weeks old BALB/c female mice with JC mammary adenocarcinoma cells
Dosage:	75 mg/kg
Administration:
Result:	Tumor growth was significantly lower (>50% decreased at day 18) than tumor growth in control animals.

target

IC50: 2 μM (GST-hSK), 6 μM (hPI3k) and 80 μM (ERK2)

References

[1] French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. PMID:14522923
[2] French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318(2):596-603. DOI:10.1124/jpet.106.101345

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Preparation Products And Raw materials

Raw materials

Preparation Products

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24418-86-8, 2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor VRelated Search:

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

SKI V

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one

Sphingosine Kinase Inhibitor V

(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one

(2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one

3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-

2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one

PI3K,SKI V,Inhibitor,Apoptosis,GST-hSK,sphingosine,second,mitogenic,Phosphoinositide 3-kinase,S1P,Sphingosine kinase,kinase,SphK,inhibit,antitumor,noncompetitive,messenger,non-lipid

SKI V, 10 mM in DMSO

24418-86-8