ChemicalBook > CAS DataBase List > 2-Cyano-N,N-diethylacetamide

2-Cyano-N,N-diethylacetamide

Product Name
2-Cyano-N,N-diethylacetamide
CAS No.
26391-06-0
Chemical Name
2-Cyano-N,N-diethylacetamide
Synonyms
DEFA;N,N-DIETHYLCYANOACETAMIDE;N,N-diethyl caynoacetaMide;2-Cyano-N,N-diethylacetaMid;2-Cyano-N,N-diethylacetamide;N,N-Diethyl-2-cyanoacetoamide;Acetamide, 2-cyano-N,N-diethyl-;2-Cyano-N,N-diethylacetamide >2-Cyano-N,N-diethylacetamide;N,N-Diethyl-2-cyanoacetoamide
CBNumber
CB22130981
Molecular Formula
C7H12N2O
Formula Weight
140.18
MOL File
26391-06-0.mol
More
Less

2-Cyano-N,N-diethylacetamide Property

Melting point:
121 °C
Boiling point:
114°C/4mmHg(lit.)
Density 
1.013 g/mL at 25 °C
refractive index 
n20/D1.466
Flash point:
>110℃
storage temp. 
2-8°C
solubility 
Chloroform, Ethyl Acetate, Tetrahydrofuran, Methanol
form 
Oil
pka
4.53±0.10(Predicted)
color 
Light Yellow to Light Brown
InChI
InChI=1S/C7H12N2O/c1-3-9(4-2)7(10)5-6-8/h3-5H2,1-2H3
InChIKey
RYSHIRFTLKZVIH-UHFFFAOYSA-N
SMILES
C(N(CC)CC)(=O)CC#N
CAS DataBase Reference
26391-06-0(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2926907090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
761133
Product name
N,N-Diethyl-2-cyanoacetoamide
Purity
97%
Packaging
5g
Price
$187
Updated
2025/07/31
Sigma-Aldrich
Product number
761133
Product name
N,N-Diethyl-2-cyanoacetoamide
Purity
97%
Packaging
25g
Price
$913
Updated
2025/07/31
TCI Chemical
Product number
C2822
Product name
2-Cyano-N,N-diethylacetamide
Purity
>98.0%(GC)
Packaging
5g
Price
$67
Updated
2025/07/31
TCI Chemical
Product number
C2822
Product name
2-Cyano-N,N-diethylacetamide
Purity
>98.0%(GC)
Packaging
25g
Price
$168
Updated
2021/12/16
TRC
Product number
D444140
Product name
N,N-Diethylcyanoacetamide
Packaging
2g
Price
$70
Updated
2021/12/16
More
Less

2-Cyano-N,N-diethylacetamide Chemical Properties,Usage,Production

Chemical Properties

Pale Brown Oil

Uses

N,N-Diethyl-2-cyanoacetoamide can be used:

  • To prepare N,N-diethyl 2-cyano-2-fluoro-2-phenylthioacetoamide, which is further used in the synthesis of various cyanofluoroamides.
  • In the synthesis of entacapone, a catechol-O-methyltransferase inhibitor by reacting with 3,4-dihydroxy-5-nitrobenzaldehyde.
  • As a building block in the synthesis of fluorophores, applicable as endoplasmic reticulum probes.

Definition

ChEBI: N,N-diethylcyanoacetamide is an aliphatic nitrile and a monocarboxylic acid amide.

Synthesis

109-89-7

105-56-6

26391-06-0

(i) Preparation of N1,N1-diethyl-2-cyanoacetamide: 30 L of anhydrous tetrahydrofuran (THF) was added to the reactor under nitrogen protection, followed by diethylamine (1.272 kg, 17.39 mol). A 33% hexane solution of lithium n-hexyl was loaded into a dropping funnel. The reactor was cooled to below -30°C. The hexyl lithium solution was slowly added dropwise to the reactor, keeping the temperature of the reaction mixture below -30°C during the dropwise addition. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -30 °C for 1.5 hours. Meanwhile, ethyl cyanoacetate (0.655 kg, 5.79 mol) was dissolved in THF (2 L) and transferred to another dropping funnel. The ethyl cyanoacetate solution was slowly added dropwise to the reaction mixture at a temperature well below -30°C. After completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirring was continued for 30 minutes. Subsequently, ethanol (0.66 L) was slowly added dropwise to the reaction mixture and stirred overnight at room temperature. The solvent was removed by distillation under reduced pressure and the residue was treated with 10% hydrochloric acid (8 L) and extracted twice with dichloromethane (DCM, 2 x 7 L). The DCM layers were combined and washed with water (2 × 5 L). The DCM solution was dried and evaporated to dryness to afford the brown oily product N1,N1-diethyl-2-cyanoacetamide (755.29 g, 97% yield), which could be used in the subsequent steps without further purification.1H-NMR (200 MHz, CDCl3): δ 1.2 ppm (t, 6H, J = 7Hz), 3.4 ppm (q, 4H, J = 7Hz), 3.55ppm (s, 2H).

References

[1] Patent: US2008/103191, 2008, A1. Location in patent: Page/Page column 17
[2] Australian Journal of Chemistry, 1976, vol. 29, p. 1039 - 1050
[3] Synthetic Communications, 1990, vol. 20, # 20, p. 3235 - 3243
[4] Journal of the Korean Chemical Society, 2012, vol. 56, # 4, p. 459 - 463

2-Cyano-N,N-diethylacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Cyano-N,N-diethylacetamide Suppliers

Americas 1 Canada 1 China 151 Europe 1 India 44 Japan 2 United Kingdom 2 United States 13 Global 215
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
KKyemistry (India) Pvt. Ltd.
Tel
--
Fax
--
Email
info@kyemistryindia.com
Country
India
ProdList
197
Advantage
50
ALLCHEM LIFESCIENCE PVT. LTD
Tel
--
Fax
--
Email
info@allchemlifescience.com
Country
India
ProdList
317
Advantage
58
MAKSONS FINE CHEM PVT. LTD.
Tel
--
Fax
--
Email
info@maksons.com
Country
India
ProdList
16
Advantage
58
Maksons Fine Chem Private Limited
Tel
--
Fax
--
Country
India
ProdList
13
Advantage
58
Ramdev Chemical Private Limited
Tel
--
Fax
--
Country
India
ProdList
24
Advantage
58
ENAL DRUGS PRIVATE LIMITED
Tel
--
Fax
--
Email
mktg@enaldrugs.com
Country
India
ProdList
27
Advantage
58
Trignokem International
Tel
--
Fax
--
Country
India
ProdList
110
Advantage
58
Trignokem International.
Tel
--
Fax
--
Email
ignokem@gmail.com
Country
India
ProdList
233
Advantage
58
Festiva Pharma
Tel
--
Fax
--
Country
India
ProdList
237
Advantage
58
Suryakala Laboratories Private Limited.
Tel
--
Fax
--
Email
gvr@suryakalalabs.com
Country
India
ProdList
5
Advantage
58
Kkyemistry (india) Pvt., Ltd.
Tel
--
Fax
--
Email
marketing@kyemistryindia.com
Country
India
ProdList
163
Advantage
58
Reax Chemicals
Tel
--
Fax
--
Country
India
ProdList
4217
Advantage
58
Arene Life Sciences Limited
Tel
--
Fax
--
Country
India
ProdList
164
Advantage
58
Vaishno Drugs & Intermediates Pvt Ltd.
Tel
--
Fax
--
Email
vaishnodrugs@gmail.com
Country
India
ProdList
10
Advantage
58
Bizten Impex Private Limited.
Tel
--
Fax
--
Country
India
ProdList
109
Advantage
58
Suven Life Sciences Limited
Tel
--
Fax
--
Country
India
ProdList
49
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
GANGWAL CHEMICALS PVT LTD
Tel
--
Fax
--
Email
sales@gangwalchem.com
Country
India
ProdList
75
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Hritik Chemicals Pvt., Ltd.
Tel
--
Fax
--
Email
info@hritikchemical.com
Country
India
ProdList
88
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Divis Laboratories Ltd.
Tel
--
Fax
--
Country
India
ProdList
147
Advantage
58
Bizten Impex Private Limited
Tel
--
Fax
--
Country
India
ProdList
71
Advantage
58
RA CHEM PHARMA LTD
Tel
--
Fax
--
Email
info@rachempharma.com
Country
India
ProdList
37
Advantage
58
Hritik Chemical Corporation
Tel
--
Fax
--
Country
India
ProdList
55
Advantage
58
Sibram Pharmaceutical
Tel
--
Fax
--
Email
contact@sibram.com
Country
India
ProdList
136
Advantage
58
Darsh PharmaChem Pvt. Ltd.
Tel
--
Fax
--
Email
info@darshpharmachem.com
Country
India
ProdList
27
Advantage
58
Molecraft LifeSciences Pvt Ltd
Tel
--
Fax
--
Email
info@molecraft.com
Country
India
ProdList
757
Advantage
0
Palm International
Tel
--
Fax
--
Country
India
ProdList
40
Advantage
58
Maksons Fine Chem Pvt Ltd
Tel
--
Fax
--
Country
India
ProdList
25
Advantage
58
Quiver Technologies
Tel
--
Fax
--
Country
India
ProdList
169
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Manus Aktteva
Tel
--
Fax
--
Email
info@manusaktteva.in
Country
India
ProdList
581
Advantage
34
Trignokem International
Tel
--
Fax
--
Email
info@trignokem.com
Country
India
ProdList
380
Advantage
50
More
Less

View Lastest Price from 2-Cyano-N,N-diethylacetamide manufacturers

Career Henan Chemical Co
Product
2-Cyano-N,N-diethylacetamide 26391-06-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-08

26391-06-0, 2-Cyano-N,N-diethylacetamideRelated Search:

2-Cyanoacetamide Thioacetamide DIACETAMIDE Acetamide N,N-Diethylhydroxylamine N,N-Diethylethylenediamine N,N-Dimethylacetoacetamide Diethylacetamide N,N-Dimethylacetamide 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE N-CYANOACETYLMORPHOLINE N-CYANOACETYLPYRROLIDINE 1-CYANOACETYLPIPERIDINE ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE METHYL 6-CYANO-1-HYDROXY-7-METHYL-5-OXO-3,5-DIHYDROINDOLIZINE-2-CARBOXYLATE 6-(4-CHLOROPHENYL)-1-(3,4-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE 2-Cyano-N,N-diethylacetamide

  • N,N-DIETHYLCYANOACETAMIDE
  • 2-Cyano-N,N-diethylacetamide
  • 2-Cyano-N,N-diethylacetaMid
  • N,N-diethyl caynoacetaMide
  • N,N-Diethyl-2-cyanoacetoamide
  • 2-Cyano-<i>N</i>,<i>N</i>-diethylacetamide
  • 2-Cyano-N,N-diethylacetamide &gt
  • Acetamide, 2-cyano-N,N-diethyl-
  • DEFA
  • <i>N</i>,<i>N</i>-Diethyl-2-cyanoacetoamide
  • 26391-06-0
  • Aliphatics
  • Miscellaneous Reagents
  • pharmaceutical intermediates