N,N'-DIACETYLGLYCINE ANHYDRIDE

Product Name: N,N'-DIACETYLGLYCINE ANHYDRIDE
CAS No.: 3027-05-2
Chemical Name: N,N'-DIACETYLGLYCINE ANHYDRIDE
Synonyms: N,N'-Diacetylglycine Anhydride;N,N'-DIACETYLGLYCINE ANHYDRIDE;1,4-DIACETYL-2,5-PIPERAZINEDIONE;1,4-DIACETYL-2,5-DIOXOPIPERAZINE;N,N'-diacetyipiperazin-2,5-dione;1,4-DIACETYL-2,5-DIKETOPIPERAZINE;N,N′-Diacetyl-2,5-dioxopiperazine;1,4-DIACETYL-PIPERAZINE-2,5-DIONE;N,N'-Diacetylglycine Anhydride >2,5-Piperazinedione, 1,4-diacetyl-
CBNumber: CB2223539
Molecular Formula: C8H10N2O4
Formula Weight: 198.18
MOL File: 3027-05-2.mol

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N,N'-DIACETYLGLYCINE ANHYDRIDE Property

Melting point:: 99-100°C
Boiling point:: 424.4±38.0 °C(Predicted)
Density: 1.375±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: -1.74±0.20(Predicted)
color: White to Light yellow to Light orange
BRN: 188115
InChI: InChI=1S/C8H10N2O4/c1-5(11)9-3-8(14)10(6(2)12)4-7(9)13/h3-4H2,1-2H3
InChIKey: CBBKKVPJPRZOCM-UHFFFAOYSA-N
SMILES: N1(C(C)=O)CC(=O)N(C(C)=O)CC1=O

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-43-36/38-22
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3
HS Code: 2933.59.9500
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D1073
Product name: N,N'-Diacetylglycine Anhydride
Purity: >98.0%(GC)
Packaging: 10g
Price: $223
Updated: 2025/07/31

Matrix Scientific

Product number: 043190
Product name: 1,4-Diacetyltetrahydro-2,5-pyrazinedione
Purity: >95%
Packaging: 5g
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 9529AD
Product name: 1,4-Diacetyltetrahydro-2,5-pyrazinedione
Packaging: 5g
Price: $211
Updated: 2021/12/16

Chem-Impex

Product number: 43343
Product name: N,N'-Diacetylglycineanhydride,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 10G
Price: $268.09
Updated: 2021/12/16

Oakwood

Product number: 080152
Product name: 1,4-Diacetylpiperazine-2,5-dione
Purity: 98%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

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N,N'-DIACETYLGLYCINE ANHYDRIDE Chemical Properties,Usage,Production

Description

?N,N'-diacetylglycine anhydride, also known as diacetylated glycylglycine, can be obtained by acylation of glycylglycine with acetic anhydride. N,N'-diacetylglycine anhydride can be used to prepare DL-neopentylglycine derivatives.

Preparation

After the mixed reaction of glycylglycine and acetic anhydride, ethyl acetate and petroleum ether are added in sequence to obtain the intermediate N,N'-diacetylglycine anhydride.

Application

N,N'-diacetylglycine anhydride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process.

Synthesis

106-57-0

108-24-7

3027-05-2

GENERAL METHOD: 2,5-Piperazinedione (500 mg, 2.5 mmol) was mixed with ethanoic anhydride (20 mL) and reacted at 150°C overnight. Upon completion of the reaction, the excess acetic anhydride was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography to afford 1,4-diacetylpiperazine-2,5-dione.

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2554 - 2561
[2] Synthesis (Germany), 2014, vol. 46, # 5, p. 621 - 628
[3] European Journal of Medicinal Chemistry, 2014, vol. 83, p. 236 - 244
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 11, p. 1217 - 1224
[5] Tetrahedron, 2012, vol. 68, # 36, p. 7374 - 7379

N,N'-DIACETYLGLYCINE ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-DIACETYLGLYCINE ANHYDRIDE Suppliers

Americas 1 China 100 Europe 2 France 1 Germany 1 India 2 Japan 1 Ukraine 1 United Kingdom 2 United States 11 Global 122

Key Organics Ltd.

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Email: info@keyorganics.net
Country: United Kingdom
ProdList: 6741
Advantage: 50

CARBONE SCIENTIFIC CO.,LTD

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Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

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View Lastest Price from N,N'-DIACETYLGLYCINE ANHYDRIDE manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: N,N'-Diacetylglycine Anhydride 3027-05-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2 MTs
Release date: 2024-08-06

Dideu Industries Group Limited

Product: N,N'-DIACETYLGLYCINE ANHYDRIDE 3027-05-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-23

Career Henan Chemical Co

Product: N,N'-DIACETYLGLYCINE ANHYDRIDE 3027-05-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

3027-05-2, N,N'-DIACETYLGLYCINE ANHYDRIDERelated Search:

3,6-Pyridazinedione, 1,2-diacetyltetrahydro- 1,4-DIFORMYLPIPERAZINE GLYCINE ANHYDRIDE 1,4-DIACETYL-3,6-DIBENZYLTETRAHYDRO-2,5-PYRAZINEDIONE 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE 1-Piperazinecarbaldehyde Piperazine, 1,4-diacetyl- (6CI,8CI,9CI) 1-ETHYLPIPERAZIN-2-ONE N,N'-DIACETYLGLYCINE ANHYDRIDE SARCOSINE ANHYDRIDE 1-Methylpiperazin-2-one 2-Piperazinone N,N'-DIACETYLETHYLENEDIAMINE 1-FORMYL-4-METHYLPIPERAZINE 1-Acetylpiperazine

1,4-DIACETYL-PIPERAZINE-2,5-DIONE

1,4-DIACETYLTETRAHYDRO-2,5-PYRAZINEDIONE

1,4-DIACETYL-2,5-DIKETOPIPERAZINE

1,4-DIACETYL-2,5-DIOXOPIPERAZINE

1,4-DIACETYL-2,5-PIPERAZINEDIONE

N,N′-Diacetyl-2,5-dioxopiperazine

2,5-Piperazinedione, 1,4-diacetyl-

<i>N</i>,<i>N</i>'-Diacetylglycine Anhydride

1,4-Diacetyl-2,5-diketopiperazine 1,4-Diacetyl-2,5-dioxopiperazine 1,4-Diacetyl-2,5-piperazinedione

N,N'-Diacetylglycine Anhydride &gt

N,N'-DIACETYLGLYCINE ANHYDRIDE ISO 9001：2015 REACH

N,N'-Diacetylglycine Anhydride

1,4-Diacetyl-2,5-piperazinedione - [D94521]

N,N'-DIACETYLGLYCINE ANHYDRIDE

N,N'-diacetyipiperazin-2,5-dione

3027-05-2

3027-5-2

411751