2-Chloro-5-methylsulfanylbenzoic acid
- Product Name
- 2-Chloro-5-methylsulfanylbenzoic acid
- CAS No.
- 51546-12-4
- Chemical Name
- 2-Chloro-5-methylsulfanylbenzoic acid
- Synonyms
- TOME-1;LABOTEST-BB LT00452880;Gene-rich cluster protein C8;Trigger of mitotic entry protein 1;2-CHLORO-5-(METHYLTHIO)BENZOIC ACID;2-Chloro-5-methylsulfanylbenzoicaci;2-CHLORO-5-METHYLSULFANYLBENZOIC ACID;Benzoic acid, 2-chloro-5-(methylthio)-;Cell division cycle-associated protein 3;2-CHLORO-5-(METHYLTHIO)BENZOIC ACID TECH 98.0%
- CBNumber
- CB2228534
- Molecular Formula
- C8H7ClO2S
- Formula Weight
- 202.66
- MOL File
- 51546-12-4.mol
2-Chloro-5-methylsulfanylbenzoic acid Property
- Melting point:
- 136-137 °C (lit.)
- Boiling point:
- 342.4±32.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.74±0.25(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
- biological source
- rabbit
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HS Code
- 2930909899
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 245380
- Product name
- 2-Chloro-5-(methylthio)benzoic acid
- Purity
- technical grade, 96%
- Packaging
- 10g
- Price
- $214.9
- Updated
- 2025/07/31
- Product number
- SAB4503278
- Product name
- Anti-CDCA3, C-Terminal antibody produced in rabbit
- Purity
- affinity isolated antibody
- Packaging
- 100μG
- Price
- $485
- Updated
- 2023/01/07
- Product number
- 245380
- Product name
- 2-Chloro-5-(methylthio)benzoic acid
- Purity
- technical grade, 96%
- Packaging
- 50g
- Price
- $600
- Updated
- 2023/01/07
- Product number
- C587598
- Product name
- 2-Chloro-5-(methylthio)benzoic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 184513
- Product name
- 2-Chloro-5-(methylthio)benzoic acid
- Packaging
- 0.500g
- Price
- $100
- Updated
- 2021/12/16
2-Chloro-5-methylsulfanylbenzoic acid Chemical Properties,Usage,Production
Uses
2-Chloro-5-(methylthio)benzoic acid may be used in chemical synthesis studies.
Synthesis
886973-19-9
544-92-3
127510-97-8
51546-12-4
Methyl 2-chloro-5-(methylthio)benzoate (23.2 g, 106.9 mmol) and cuprous cyanide (19.2 g, 213.8 mmol) were dissolved in 100 mL of N-methylpyrrolidone. The reaction mixture was heated at 160 °C for 72 hours. The progress of the reaction was monitored by LCMS, which showed the presence of cyanide ester and hydrolyzed acid in a 1:1 ratio. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently treated with 250 mL of water and 300 mL of ethyl acetate and filtered through diatomaceous earth. After separating the organic and aqueous phases, the aqueous phase was extracted with 2 x 250 mL of ethyl acetate. The organic phases were combined, washed with 250 mL of water, dried over MgSO4 and concentrated to give an oily crude product. The crude product was purified by combi fast silica gel column chromatography using a hexane solution of 0-20% ethyl acetate as eluent, resulting in methyl 2-cyano-5-(methylthio)benzoate (6.14 g, 28% yield) as a white solid.The LCMS analysis showed the following: retention time (Rt) = 2.42 min; mass-to-charge ratio (m/z) [M + H]+ = 208.
References
[1] Patent: WO2006/67462, 2006, A1. Location in patent: Page/Page column 61
2-Chloro-5-methylsulfanylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-5-methylsulfanylbenzoic acid manufacturers
- Product
- 2-Chloro-5-methylsulfanylbenzoic acid 51546-12-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17
- Product
- 2-Chloro-5-methylsulfanylbenzoic acid 51546-12-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-05