CALPAIN INHIBITOR XII
- Product Name
- CALPAIN INHIBITOR XII
- CAS No.
- 181769-57-3
- Chemical Name
- CALPAIN INHIBITOR XII
- Synonyms
- Z-L-NVA-CONH-CH2-2-PY;CALPAIN INHIBITOR XII;(Rac)-Calpain Inhibitor XII;PLVWMBFPIAQRHK-UHFFFAOYSA-N;benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate;Carbamic acid, [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-, phenylmethyl ester (9CI)
- CBNumber
- CB2243292
- Molecular Formula
- C26H34N4O5
- Formula Weight
- 482.57
- MOL File
- Mol file
CALPAIN INHIBITOR XII Property
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤16mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 10.58±0.46(Predicted)
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- J64751
- Product name
- Calpain Inhibitor XII
- Packaging
- 1mg
- Price
- $111
- Updated
- 2023/06/20
- Product number
- J64751
- Product name
- Calpain Inhibitor XII
- Packaging
- 5mg
- Price
- $463
- Updated
- 2023/06/20
- Product number
- 14466
- Product name
- Calpain Inhibitor XII
- Purity
- ≥90%
- Packaging
- 1mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 14466
- Product name
- Calpain Inhibitor XII
- Purity
- ≥90%
- Packaging
- 5mg
- Price
- $449
- Updated
- 2024/03/01
- Product number
- 14466
- Product name
- Calpain Inhibitor XII
- Purity
- ≥90%
- Packaging
- 10mg
- Price
- $747
- Updated
- 2024/03/01
CALPAIN INHIBITOR XII Chemical Properties,Usage,Production
Description
Calpain inhibitor XII is a reversible and selective inhibitor of calpain I (μ-
Uses
A cell-permeable dipeptidyl -ketoamide compound that acts as a potent, selective, reversible, and active site inhibitor of calpain-1
in vitro
a series of new dipeptidyl alpha-keto amides of the general structure r1-l-leu-d,l-aa-conh-r2 including calpain inhibitor xii were synthesized and evaluated as inhibitors for the cysteine proteases calpain i, calpain ii, and cathepsin b. calpain ii was more sensitive to these inhibitors calpain inhibitor xii than calpain i. calpain i was also effectively inhibited by calpain inhibitor xii, but lower ki values than with calpain ii. cathepsin b was weakly inhibited by calpain inhibitor xii. the best calpain i inhibitor in this study was calpain inhibitor xii with ki value of 19 nm [1].
References
[1] li, z. ,ortega-vilain, a.c.,patil, g.s., et al. novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases. journal of medicinal chemistry 39(20), 4089-4098 (1996).
CALPAIN INHIBITOR XII Preparation Products And Raw materials
Raw materials
Preparation Products
CALPAIN INHIBITOR XII Suppliers
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52925
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apexbt.com
- Country
- United States
- ProdList
- 6251
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- info@creative-enzymes.com
- Country
- United States
- ProdList
- 6057
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
- Tel
- --
- Fax
- --
- technical@calbiochem.com
- Country
- United States
- ProdList
- 6529
- Advantage
- 66
View Lastest Price from CALPAIN INHIBITOR XII manufacturers
- Product
- CALPAIN INHIBITOR XII 181769-57-3
- Price
- US $17.00/g
- Min. Order
- 25g
- Purity
- 95%
- Supply Ability
- 1KG
- Release date
- 2020-10-27