IPI-926

Product Name: IPI-926
CAS No.: 1037210-93-7
Chemical Name: IPI-926
Synonyms: IP 9;FIN 5;IPI-926;Saridegib;Patidegib);Saridegib (IPI-926;IPI-926 (SARIDEGIB);Saridegib (Synonyms: IPI-926;N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide;N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide
CBNumber: CB22506021
Molecular Formula: C29H48N2O3S
Formula Weight: 504.77
MOL File: 1037210-93-7.mol

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IPI-926 Property

Boiling point:: 617.7±65.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 10.85±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0004809
Product name: IPI-926
Purity: 95.00%
Packaging: 5MG
Price: $503.23
Updated: 2021/12/16

ChemScene

Product number: CS-0007501
Product name: Saridegib
Purity: >99.0%
Packaging: 5mg
Price: $1600
Updated: 2021/12/16

ChemScene

Product number: CS-0007501
Product name: Saridegib
Purity: >99.0%
Packaging: 10mg
Price: $2600
Updated: 2021/12/16

DC Chemicals

Product number: DC12276
Product name: Saridegib(IPI-926;Patidegib)
Purity: >98%
Packaging: 1g
Price: $7600
Updated: 2021/12/16

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IPI-926 Chemical Properties,Usage,Production

Uses

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Definition

ChEBI: Patidegib is a member of piperidines.

in vivo

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model^[1].

References

[1] Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5. DOI:10.1097/MPA.0000000000000458

IPI-926 Preparation Products And Raw materials

Raw materials

Preparation Products

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1037210-93-7, IPI-926Related Search:

IPI-926

FIN 5

IP 9

Saridegib

N-[(2S,3R,3'R,3aS,4'aR,6S,6'aR,6'bS,7aR,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-Eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]-methanesulfonamide

N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide

Saridegib (IPI-926

IPI-926 (SARIDEGIB)

Patidegib)

Saridegib (Synonyms: IPI-926

Methanesulfonamide, N-[(2S,3R,3'R,3aS,4'aR,6S,6'aR,6'bS,7aR,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]-

N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide

1037210-93-7

C29H48N2O3S