(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt

Product Name: (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
CAS No.: 1303993-73-8
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt
Synonyms: CHPG Sodium salt;(R,S)-CHPG sodium salt, mGlu5 agonist;(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt;(R,S)-CHPG sodium salt, mGlu5 agonist, water soluble
CBNumber: CB22518684
Molecular Formula: C8H7ClNNaO3
Formula Weight: 225.6
MOL File: 1303993-73-8.mol

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(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Property

storage temp.: Store at RT
solubility: Soluble to 50 mM in water and to 50 mM in DMSO
form: Powder
color: Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 3695
Product name: CHPGSodiumsalt
Purity: ≥99%(HPLC)
Packaging: 10
Price: $139
Updated: 2021/12/16

Tocris

Product number: 3695
Product name: CHPGSodiumsalt
Purity: ≥99%(HPLC)
Packaging: 50
Price: $574
Updated: 2021/12/16

Usbiological

Product number: 254968
Product name: CHPG Sodium salt
Packaging: 10mg
Price: $380
Updated: 2021/12/16

TRC

Product number: C381358
Product name: CHPGSodiumSalt
Packaging: 100mg
Price: $915
Updated: 2021/12/16

ApexBio Technology

Product number: B7475
Product name: CHPGSodiumsalt
Packaging: 10mg
Price: $204
Updated: 2021/12/16

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(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Chemical Properties,Usage,Production

Uses

CHPG Sodium Salt (cas# 1303993-73-8) is a useful research chemical.Also, it is derived from 2-Chloro-5-hydroxybenzaldehyde (C368225), which is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine.

Biological Activity

CHPG sodium salt is a selective mGluR5 agonist and attenuates SO2-induced oxidative stress and inflammation in BV2 microglia via the TSG-6/NF-κB pathway. It prevents traumatic brain injury (TBI) in vitro and in vivo through the ERK and Akt pathways.

in vitro

CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO ₂ derivatives treatment.
It protects BV2 cells against SO ₂ -induced apoptosis.
It treatment alone increases the expression of TSG-6 in both mRNA and protein levels.

Cell Viability Assay

Cell Line:	BV2 microglial cells
Concentration:	10, 50, 100 and 500 μM
Incubation Time:	24 hours
Result:	Increased the cell viability.

< p class="cpd-mod-vv-tit "> Apoptosis Analysis

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Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Protected BV2 cells against SO ₂ -induced apoptosis.

Western Blot Analysis

Cell Line:	BV2 microglial cells
Concentration:	0.5 mM
Incubation Time:	30 mins
Result:	Increased the expression of TSG-6 in both mRNA and protein levels.

Animal Model:	Adult Sprague-Dawley male rats weighing 280-320 g
Dosage:	250 nM < /td>
Administration:	Injection; for 7 days
Reduced significantly cerebral lesion volume.

(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt

(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Property

Hazard and Precautionary Statements (GHS)

N-Bromosuccinimide Price

(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Chemical Properties,Usage,Production

Uses

Biological Activity

in vitro

in vivo

target

storage

(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Preparation Products And Raw materials

Raw materials

Preparation Products

(RS)-2-Chloro-5-hydroxyphenylglycinesodiumsalt Suppliers

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