3-PyridinaMine, 2-Methyl-6-(Methylsulfonyl)-

3-PyridinaMine, 2-Methyl-6-(Methylsulfonyl)- Property

Boiling point:

441.0±45.0 °C(Predicted)

Density 

1.302±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

0.00±0.22(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

3-PyridinaMine, 2-Methyl-6-(Methylsulfonyl)- Chemical Properties,Usage,Production

Synthesis

Example 3.2: Preparation of 2-methyl-6-(methylsulfonyl)pyridin-3-amine (Method 1); 6-bromo-2-methylpyridin-3-amine (40.0 g, 214 mmol), sodium methanesulfinate (87.3 g, 855 mmol), copper(I)-benzene trifluoromethanesulfonate complex (10.8 g, 21.4 mmol), and N1,N2-dimethyl Ethane-1,2-diamine (10.8 g, 21.4 mmol) in a solution of DMSO (300 mL) was heated at 150 °C for 4 hours. After the reaction was completed, it was cooled to room temperature and H2O (100 mL) was added. The dark brown solution was extracted with ethyl acetate (6 x 30 mL). The organic layer was washed with H2O (100 mL) to remove DMSO. the aqueous layer was back-extracted three times with ethyl acetate. All organic layers were combined, washed with brine, dried over Na2SO4 and filtered. After concentrating the filtrate under reduced pressure to about 200 mL, the solid product precipitated and was collected by filtration to give the title compound (24.0 g, 60% yield) as a brown powder. The compound was characterized by LC-MS and 1H NMR: the exact mass of C7H10N2O2S was calculated to be 186.1 and the measured LC-MS m/z was 187.1 (M+H)+; 1H NMR (400 MHz, CDCl3) δ 2.44 (s, 3H), 3.13 (s, 3H), 4.66 (bs, 2H), 7.01 (d, J=), 8.34 Hz, 1H. 8.34 Hz, 1H), 7.71 (d, J=8.34 Hz, 1H).

References

[1] Patent: WO2008/5576, 2008, A1. Location in patent: Page/Page column 28