ChemicalBook > CAS DataBase List > CAY10512
CAY10512
- Product Name
- CAY10512
- CAS No.
- 139141-12-1
- Chemical Name
- CAY10512
- Synonyms
- CAY10512;1-fluoro-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene;Benzene, 1-fluoro-2-[(1E)-2-(4-methoxyphenyl)ethenyl]-;NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem
- CBNumber
- CB22590420
- Molecular Formula
- C15H13FO
- Formula Weight
- 228.262
- MOL File
- 139141-12-1.mol
More
Less
CAY10512 Property
- Melting point:
- 100-101 °C
- Boiling point:
- 340.4±11.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- DMF: 3 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml; DMSO: 2 mg/ml; Ethanol: 0.5 mg/ml
- form
- Crystalline solid
- color
- White to off-white
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 481412
- Product name
- NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem
- Packaging
- 10mg
- Price
- $189
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 10009536
- Product name
- CAY10512
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $45
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10009536
- Product name
- CAY10512
- Purity
- ≥97%
- Packaging
- 50mg
- Price
- $198
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10009536
- Product name
- CAY10512
- Purity
- ≥97%
- Packaging
- 100mg
- Price
- $351
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10009536
- Product name
- CAY10512
- Purity
- ≥97%
- Packaging
- 500mg
- Price
- $1528
- Updated
- 2024/03/01
More
Less
CAY10512 Chemical Properties,Usage,Production
Uses
CAY10512 is an inhibitor of NF-κB. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid, and can be used for research on Alzheimer's disease[1].
General Description
A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
Biochem/physiol Actions
Cell permeable: yes
References
[1] Alexandrov P N, et al. microRNA (miRNA) speciation in Alzheimer’s disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)[J]. International journal of biochemistry and molecular biology, 2012, 3(4): 365.
CAY10512 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
CAY10512 Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4798
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 1-400-889-1988 400-889-1988
- bioscience@merckgroup.com
- Country
- China
- ProdList
- 6839
- Advantage
- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 021-60936350
- scbt@scbt.com
- Country
- China
- ProdList
- 6594
- Advantage
- 58
- Tel
- 14748676110
- Country
- CHINA
- ProdList
- 112
- Advantage
- 58
- Tel
- 02158116080
- Country
- CHINA
- ProdList
- 147
- Advantage
- 58
- Tel
- 18566777408
- Country
- CHINA
- ProdList
- 156
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6648
- Advantage
- 58
- Tel
- --
- Fax
- --
- 470003480@QQ.COM
- Country
- CHINA
- ProdList
- 6955
- Advantage
- 58
- Tel
- --
- Fax
- --
- shxiyuanbio@163.com
- Country
- CHINA
- ProdList
- 6906
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@xarxbio.com
- Country
- China
- ProdList
- 1774
- Advantage
- 50
- Tel
- --
- Fax
- --
- info@f-biology.com
- Country
- CHINA
- ProdList
- 6170
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1985563437@qq.com
- Country
- CHINA
- ProdList
- 6525
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6600
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6151
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2453006496@qq.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- 978560024@qq.com
- Country
- CHINA
- ProdList
- 6458
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810200961@163.com
- Country
- CHINA
- ProdList
- 6643
- Advantage
- 58