Tenofovir (Maleate)

Product Name: Tenofovir (Maleate)
CAS No.: 1236287-04-9
Chemical Name: Tenofovir (Maleate)
Synonyms: Tenofovir (Maleate)
CBNumber: CB22677048
Molecular Formula: C13H18N5O8P
Formula Weight: 403.29
MOL File: 1236287-04-9.mol

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Tenofovir (Maleate) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1253
Product name: Tenofovirmaleate
Packaging: 5mg
Price: $74
Updated: 2021/12/16

ApexBio Technology

Product number: B1253
Product name: Tenofovirmaleate
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ApexBio Technology

Product number: B1253
Product name: Tenofovirmaleate
Packaging: 50mg
Price: $221
Updated: 2021/12/16

Crysdot

Product number: CD31004142
Product name: Tenofovirmaleate
Purity: 98+%
Packaging: 10mg
Price: $57
Updated: 2021/12/16

Crysdot

Product number: CD31004142
Product name: Tenofovirmaleate
Purity: 98+%
Packaging: 50mg
Price: $271
Updated: 2021/12/16

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Tenofovir (Maleate) Chemical Properties,Usage,Production

Uses

Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.

Biological Activity

tenofovir maleate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir maleate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir maleate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec50 values of tenofovir maleate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].

in vivo

Tenofovir Disoproxil Fumarate (20, 50, 140, or 300?mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300?mg/kg) significantly reduces HIV transmission in BLT mice^[3]. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection^[4].

IC 50

HIV-1

References

[1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11.

Tenofovir (Maleate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Tenofovir (Maleate) Suppliers

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Tenofovir (Maleate)

1236287-04-9