ChemicalBook > CAS DataBase List > 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

Product Name
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
CAS No.
1402830-75-4
Chemical Name
3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
Synonyms
Ceranib-2 >=98% (HPLC);Ceranib-2, 10 mM in DMSO;3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone;3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone;2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-;3-[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one
CBNumber
CB22715575
Molecular Formula
C25H19NO3
Formula Weight
381.42326
MOL File
1402830-75-4.mol
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3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Property

storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0607
Product name
Ceranib-2
Purity
≥98% (HPLC)
Packaging
5mg
Price
$82
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0607
Product name
Ceranib-2
Purity
≥98% (HPLC)
Packaging
25mg
Price
$315
Updated
2025/07/31
Cayman Chemical
Product number
11092
Product name
Ceranib-2
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
11092
Product name
Ceranib-2
Purity
≥98%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
11092
Product name
Ceranib-2
Purity
≥98%
Packaging
25mg
Price
$270
Updated
2024/03/01
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3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Chemical Properties,Usage,Production

Description

Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells). It also increases intracellular accumulation of various ceramides, including C14 ceramide , C24 ceramide , C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model.

Uses

Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity[1][2].

in vivo

Ceranib-2 (20-50 mg/kg; intraperitoneal injection; daily for 5 days per week; for 3 weeks; female Balb/c mice) treatment delays tumor growth in a syngeneic tumor model without hematologic suppression or overt signs of toxicity[1].
Intraperitoneal administration of 50 mg/kg Ceranib-2 results in progressive increases in its circulating levels, reaching a peak plasma concentration of approximately 40 μM at the 2 hr time point. Ceranib-2 appears to be cleared with a half-life of less than 2 hr[1].

Animal Model:Female Balb/c mice injected with JC murine mammary adenocarcinoma cells[1]
Dosage:20 mg/kg or 50 mg/kg
Administration:Intraperitoneal injection; daily for 5 days per week; for 3 weeks
Result:Delayed tumor growth in a syngeneic tumor model.

References

[1] Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61. DOI:10.1158/1535-7163.MCT-11-0365
[2] Kus G, et al. Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1056-63. DOI:10.1007/s11626-015-9932-9

3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone Suppliers

China 19 United States 9 Global 28
BOC Sciences
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1-631-485-4226; 16314854226
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DKMbiochem.Co. Ltd
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15901859516
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15901859516
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sales@DKMbiochem.com
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China
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BOC Sciences
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16314854226
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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Beijing Jin Ming Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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sales@chemegen.com
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MedBioPharmaceutical Technology Inc
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order@med-bio.cn
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Energy Chemical
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021-58436166
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marketing@energy-chemical.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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China
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1402830-75-4, 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinoneRelated Search:


  • 3-[3-(4-Methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone
  • 3-[3-(4-Methoxyphenyl)-1-oxo-2-propenyl]-4-phenyl-2(1H)-quinolinone
  • 2(1H)-Quinolinone, 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-
  • Ceranib-2 >=98% (HPLC)
  • Ceranib-2, 10 mM in DMSO
  • 3-[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one
  • 1402830-75-4