ReModelin hydrobroMide

Product Name: ReModelin hydrobroMide
CAS No.: 1622921-15-6
Chemical Name: ReModelin hydrobroMide
Synonyms: CS-1751;Remodelin HBR;ReModelin hydrobroMide;ReModelin hydrobroMide USP/EP/BP;4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide;4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1);Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1);HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase;Remodelin 16066 Remodelin (hydrobromide) 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
CBNumber: CB22729374
Molecular Formula: C15H15BrN4S
Formula Weight: 363.2754
MOL File: 1622921-15-6.mol

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ReModelin hydrobroMide Property

storage temp.: Store at -20°C
solubility: ≥36.3 mg/mL in DMSO; insoluble in H2O; ≥2.6 mg/mL in EtOH with ultrasonic
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16066
Product name: Remodelin (hydrobromide)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16066
Product name: Remodelin (hydrobromide)
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16066
Product name: Remodelin (hydrobromide)
Purity: ≥98%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

TRC

Product number: R143650
Product name: Remodelin hydrobromide
Packaging: 1mg
Price: $45
Updated: 2021/12/16

TRC

Product number: R143650
Product name: Remodelin hydrobromide
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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ReModelin hydrobroMide Chemical Properties,Usage,Production

Uses

Remodelin acts as a potent acetyl-transferase NAT10 inhibitor, which is shown to correct defects of laminopathic cells. Anti-aging.

Biological Activity

remodelin is a potent inhibitor of nat10 [1].n-acetyltransferase 10 (nat10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. nat10 mainly exists in the nucleolus.remodelin is a potent nat10 inhibitor. in lamin a/c depletion (silmna) cells, remodelin remodeled nuclear architecture through inhibition of nat10 lysine acetyltransferase activity. in cells derived from lmna-mutated hgps patients and primary mrc5 fibroblasts aged in culture, remodelin significantly decreased the prevalence of misshapen nuclei. in u2os cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (fti). in hgps cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of nat10 mediated nuclear shape normalization. also, remodelin reduced dna damage signaling, reduced sun1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated atm and dna double-strand break markers γh2ax, and improved chromatin and nucleolar organization. in silmna and hgps cells, remodelin inhibited microtubule anchorage to centrosomes [1].

References

[1]. larrieu d, britton s, demir m, et al. chemical inhibition of nat10 corrects defects of laminopathic cells. science, 2014, 344(6183): 527-532.

ReModelin hydrobroMide Preparation Products And Raw materials

Raw materials

Preparation Products

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ReModelin hydrobroMide Suppliers

China 67 United States 13 Global 80

MedChemexpress LLC

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View Lastest Price from ReModelin hydrobroMide manufacturers

Career Henan Chemical Co

Product: Remodelin (hydrobromide) 1622921-15-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

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ReModelin hydrobroMide

Remodelin HBR

4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1)

Remodelin 16066 Remodelin (hydrobromide) 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)

CS-1751

4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile

ReModelin hydrobroMide USP/EP/BP

4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide

HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase

1622921-15-6

C15H14N4SHBr

C15H15BrN4S

Inhibitors

ReModelin