ChemicalBook > CAS DataBase List > [4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone

[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone

Product Name
[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone
CAS No.
1402612-62-7
Chemical Name
[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone
Synonyms
KT182;KT182,KT-182;KT182 >=98% (HPLC);KT182, 10 mM in DMSO;[4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenyl-1-piperidyl)methanone;[3-(4-{1-[(2-phenylpiperidin-1-yl)carbonyl]-1,2,3-triazol-4-yl}phenyl)phenyl]methanol - [AC77808];[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone;Methanone, [4-[3'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-
CBNumber
CB22756024
Molecular Formula
C27H26N4O2
Formula Weight
438.52
MOL File
1402612-62-7.mol
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[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone Property

Boiling point:
684.3±65.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
14.21±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1248
Product name
KT182
Purity
≥98% (HPLC)
Packaging
5mg
Price
$100
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1248
Product name
KT182
Purity
≥98% (HPLC)
Packaging
25mg
Price
$393
Updated
2025/07/31
Cayman Chemical
Product number
15404
Product name
KT182
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
15404
Product name
KT182
Purity
≥98%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
15404
Product name
KT182
Purity
≥98%
Packaging
10mg
Price
$195
Updated
2024/03/01
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[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone Chemical Properties,Usage,Production

Description

KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 1.7, 15.1, and 0.24 nM using Neuro2a membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2a cells in situ, respectively. Following administration of KT182 (1 mg/kg, i.p.) in mice, ABHD6 is inactivated in liver and brain extracts, suggesting that it is brain-penetrant, unlike the closely related compound KT203 .

Uses

KT182 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells[1].

in vitro

the in-vitro potencies were tested for kt182 and the results found that kt182 could potently inhibit abhd6 as measured by gelbased competitive abpp and 2-ag hydrolysis assays. moreover, the in-situ potencies were measured by treating neuro2a cells with varying concentrations of kt182 for 4 h, and it was found that kt182 could inhibit abhd6 with ic50 values in the subnanomolar range [1].

in vivo

in animal study, mice were treated intraperitoneally with kt182 at various doses (0.1-1 mg/kg) for 4 h, and the results found that kt182 could produce near-complete blockade of abhd6 in the liver at the highest dose tested. moreover, kt182 at lower doses maintained around 80% inhibition of abhd6 in the liver and kt182 at higher doses showed impressive selectivity in the mouse liver, exhibiting little cross-reactivity against the numerous carboxylesterase enzymes. in addition, kt182 could also completely inactivate abhd6 in the mouse brain at 1 mg/kg [1].

IC 50

< 5 nm

storage

Store at -20°C

References

[1] hsu kl, tsuboi k, chang jw, whitby lr, speers ae, pugh h, cravatt bf. discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (abhd6). j med chem. 2013 nov 14;56(21):8270-9.

[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone Suppliers

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1402612-62-7, [4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanoneRelated Search:


  • [4-[3′-(Hydroxymethyl)[1,1′-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-methanone
  • KT182
  • Methanone, [4-[3'-(hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)-
  • KT182 >=98% (HPLC)
  • [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenyl-1-piperidyl)methanone
  • KT182,KT-182
  • KT182, 10 mM in DMSO
  • [3-(4-{1-[(2-phenylpiperidin-1-yl)carbonyl]-1,2,3-triazol-4-yl}phenyl)phenyl]methanol - [AC77808]
  • 1402612-62-7