ChemicalBook > CAS DataBase List > TCS HDAC6 20b

TCS HDAC6 20b

Product Name
TCS HDAC6 20b
CAS No.
956154-63-5
Chemical Name
TCS HDAC6 20b
Synonyms
TCS HDAC6 20b;DQZMLPMCOMRJOR-MOVGKWKRSA-N;S-[(6S)-7-(1-adamantylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-7-oxoheptyl] 2-methylpropanethioate;2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester;Propanethioic acid, 2-methyl-, S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
CBNumber
CB23037557
Molecular Formula
C26H44N2O4S
Formula Weight
480.7
MOL File
956154-63-5.mol
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TCS HDAC6 20b Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
White Oily foam
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14977
Product name
TCS HDAC6 20b
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14977
Product name
TCS HDAC6 20b
Purity
≥95%
Packaging
5mg
Price
$145
Updated
2024/03/01
Tocris
Product number
4805
Product name
TCSHDAC620b
Purity
≥98%(HPLC)
Packaging
10
Price
$224
Updated
2021/12/16
Usbiological
Product number
256885
Product name
TCS HDAC6 20b
Packaging
10mg
Price
$480
Updated
2021/12/16
TRC
Product number
T012700
Product name
TCSHDAC620b
Packaging
25mg
Price
$1260
Updated
2021/12/16
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TCS HDAC6 20b Chemical Properties,Usage,Production

Description

TCS HDAC6 20b is an inhibitor of histone deacetylase 6 (HDAC6) that inhibits the growth of HCT116 cells synergistically when used at a concentration of 5 μM in combination with paclitaxel , but it has no activity on cell growth in HCT116 cells when used alone. It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells.

Uses

TCS HDAC6 20b is a histone deacetylase 6 (HDAC6)-selective inhibitor.

References

[1]. suzuki t, kouketsu a, itoh y, et al. highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. j med chem, 2006, 49(16): 4809-4812.
[2]. itoh y, suzuki t, kouketsu a, et al. design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. j med chem, 2007, 50(22): 5425-5438.

TCS HDAC6 20b Preparation Products And Raw materials

Raw materials

Preparation Products

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TCS HDAC6 20b Suppliers

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956154-63-5, TCS HDAC6 20bRelated Search:


  • TCS HDAC6 20b
  • DQZMLPMCOMRJOR-MOVGKWKRSA-N
  • S-[(6S)-7-(1-adamantylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-7-oxoheptyl] 2-methylpropanethioate
  • 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
  • Propanethioic acid, 2-methyl-, S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
  • 956154-63-5
  • C26H44N2O4S