Fosravuconazole

Product Name: Fosravuconazole
CAS No.: 351227-64-0
Chemical Name: Fosravuconazole
Synonyms: E-1224);BMS-379224;Fosravuconazole;CAS:351227-64-0;SYTNEMZCCLUTNX-NPMXOYFQSA-N;Fosravuconazole (Synonyms: BMS-379224;Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
CBNumber: CB23159905
Molecular Formula: C23H20F2N5O5PS
Formula Weight: 547.47
MOL File: 351227-64-0.mol

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Fosravuconazole Property

Boiling point:: 783.7±70.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 1?+-.0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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Fosravuconazole Chemical Properties,Usage,Production

Uses

Fosravuconazole (BMS-379224), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].

Definition

ChEBI: BMS 379224 is an amine.

in vivo

Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain^[3].

Animal Model:	Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain)^[3].
Dosage:	10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg
Administration:	Oral administration; daily; for 20 days
Result:	Suppressed the parasitemia and prevented death.

References

[1] Shinichi Watanabe, et al. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study. J Dermatol. 2018 Oct;45(10):1151-1159. DOI:10.1111/1346-8138.14607
[2] Katsura Hata, et al. Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases. Parasitol Int. 2020 Dec 25;81:102278. DOI:10.1016/j.parint.2020.102278
[3] Lívia de Figueiredo Diniz, et al. Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrob Agents Chemother. 2018 May 25;62(6):e00401-18. DOI:10.1128/AAC.00401-18

Fosravuconazole Preparation Products And Raw materials

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Preparation Products

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Fosravuconazole Suppliers

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351227-64-0, FosravuconazoleRelated Search:

Fosravuconazole

SYTNEMZCCLUTNX-NPMXOYFQSA-N

E-1224)

Fosravuconazole (Synonyms: BMS-379224

BMS-379224

Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-methyl-2-[(phosphonooxy)methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-

CAS:351227-64-0

351227-64-0

C23H20F2N5O5PS