Structure
ChemicalBook > CAS DataBase List > 2-Amino-6-fluorobenzothiazole

2-Amino-6-fluorobenzothiazole

Structure
Product Name
2-Amino-6-fluorobenzothiazole
CAS No.
348-40-3
Chemical Name
2-Amino-6-fluorobenzothiazole
Synonyms
AKOS B034895;AKOS BB-8275;ASISCHEM Y86622;TIMTEC-BB SBB000158;OTAVA-BB BB7110950332;6-FLUORO-2-BENZOTHIAZOLAMINE;2-BenzothiazolaMine, 6-floro;2-AMINO-6-FLUOROBENZOTHIAZOLE;2-AMino-6-fluorobenzothiozole;2-Amino-6-Fluorolbenzothiazole
CBNumber
CB2327334
Molecular Formula
C7H5FN2S
Formula Weight
168.19
MOL File
348-40-3.mol
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2-Amino-6-fluorobenzothiazole Property

Melting point:
183-185 °C (lit.)
Boiling point:
312.0±34.0 °C(Predicted)
Density 
1.3490 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.77±0.10(Predicted)
form 
Crystalline Powder
color 
Off-white to tan
InChI
InChI=1S/C7H5FN2S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h1-3H,(H2,9,10)
InChIKey
CJLUXPZQUXVJNF-UHFFFAOYSA-N
SMILES
S1C2=CC(F)=CC=C2N=C1N
CAS DataBase Reference
348-40-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-37/39-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29342000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
324213
Product name
2-Amino-6-fluorobenzothiazole
Purity
99%
Packaging
5g
Price
$44.45
Updated
2025/07/31
TCI Chemical
Product number
A1993
Product name
2-Amino-6-fluorobenzothiazole
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$78
Updated
2025/07/31
TRC
Product number
A634633
Product name
2-Amino-6-fluorobenzothiazole
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA54338
Product name
2-Amino-6-fluorobenzothiazole
Packaging
10g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC8076
Product name
2-Amino-6-fluorobenzo-1,3-thiazole
Purity
99%
Packaging
25g
Price
$31
Updated
2021/12/16
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2-Amino-6-fluorobenzothiazole Chemical Properties,Usage,Production

Structure

Crystals of 2-amino-6-fluoro-1,3-benzothiazole, C7H5FN2S, have an amphiphilic layer-like structure. Each amino substituent donates two protons to hydrogen bonds and accepts one. The ring N atoms accept one proton. The F atoms are not involved in any hydrogen bonds.

Chemical Properties

off-white to tan crystalline powder

Uses

2-Amino-6-fluorobenzothiazole is a useful research chemical. An intermediate for the synthesis of benzothiazoles and aminobenzothiazoles with antimicrobial activity.

Definition

ChEBI: 6-Fluoro-1,3-benzothiazol-2-amine is a member of benzothiazoles.

Application

2-Amino-6-fluorobenzothiazole (AFBT) can be used for:
(1) Interaction of AFBT with β-cyclodextrin (β-CDx) in aqueous and solid state. The proton transfer behaviour of AFBT in aqueous and β-CDx solutions was studied.
(2) Spectroscopic studies. Fourier transform infrared spectroscopy (4000-400 cm-1) and Fourier transform Raman spectroscopy (4000-100 cm-1) measurements were carried out on AFBT to investigate the effect of fluorine and amino groups on the backbone pattern and proton chemical shifts.

Synthesis

333-20-0

371-40-4

348-40-3

GENERAL METHOD: 4-Fluoroaniline (0.1 mol) and potassium thiocyanate (0.4 mol) were dissolved in glacial acetic acid (40 mL) and the mixture was cooled. Bromine (0.04 mol) mixed with glacial acetic acid (24 mL) was added slowly through a dropping funnel, controlling the rate of addition to maintain the reaction temperature below 5-6°C. After the bromine was added, the reaction mixture continued to be stirred at low temperature for 2 hours. The reaction mixture was allowed to stand overnight, during which time an orange-yellow precipitate precipitated and settled to the bottom. Water was added to the mixture and the resulting slurry was heated on a steam bath at 85°C for 20 minutes, followed by filtration while hot. The filtrate was cooled and neutralized with aqueous ammonia solution to pH 6. The precipitated yellow precipitate was collected, washed with water and recrystallized by benzene to give 2-amino-6-fluorobenzothiazole crystals. The method is also applicable for the synthesis of 1,3-benzothiazol-2-amines and their derivatives 1-3 [21,22].

References

[1] Organic Letters, 2017, vol. 19, # 21, p. 5836 - 5839
[2] Molecular Crystals and Liquid Crystals, 2013, vol. 575, # 1, p. 64 - 76
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8599 - 8607
[4] Russian Journal of Applied Chemistry, 2015, vol. 88, # 12, p. 2065 - 2073
[5] Zh. Prikl. Khim. (S.-Peterburg, Russ. Fed.),

2-Amino-6-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-fluorobenzothiazole Suppliers

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View Lastest Price from 2-Amino-6-fluorobenzothiazole manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
2-Amino-6-fluorobenzothiazole 348-40-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20 tons
Release date
2025-07-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-6-fluorobenzothiazole 348-40-3
Price
US $0.00/G
Min. Order
100G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-06
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-AMINO-6-FLUOROBENZOTHIAZOLE 348-40-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-28

348-40-3, 2-Amino-6-fluorobenzothiazoleRelated Search:

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  • C7H5FN2S
  • Building Blocks
  • Thiazoles
  • Heterocyclic Building Blocks
  • amine | alkyl Fluorine
  • Heterocyclic Compounds
  • Building Blocks
  • Heterocyclic Building Blocks
  • Thiazoles
  • BENZOTHIAZOLE
  • Sulphur Derivatives