1-Boc-3-pyrrolidinecarbaldehyde
- Product Name
- 1-Boc-3-pyrrolidinecarbaldehyde
- CAS No.
- 59379-02-1
- Chemical Name
- 1-Boc-3-pyrrolidinecarbaldehyde
- Synonyms
- TERT-BUTYL 3-FORMYLPYRROLIDINE-1-CARBOXYLATE;1-BOC-3-FORMYL-PYRROLIDINE;N-BOC-3-FORMYL PYRROLIDINE;1-Boc-3-formyl-pyrrolidine 95%;-Boc-3-pyrrolidinecarbaldehyde;1-BOC-3-PYRROLIDINECARBALDEHYDE;1-boc-3-pyrrolidineearbaldehyde;N-Boc-3-pyrrolidinecarbaldehyde;(+/-)-1-Boc-3-formylpyrrolidine;1-Boc-3- pyrrolidine formaldehyde
- CBNumber
- CB2436445
- Molecular Formula
- C10H17NO3
- Formula Weight
- 199.25
- MOL File
- 59379-02-1.mol
1-Boc-3-pyrrolidinecarbaldehyde Property
- Boiling point:
- 276.3±33.0 °C(Predicted)
- Density
- 1.148±0.06 g/cm3(Predicted)
- refractive index
- 1.47
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- -2.44±0.40(Predicted)
- form
- Oil
- color
- Colourless
- InChI
- InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h7-8H,4-6H2,1-3H3
- InChIKey
- DWLADVOODHZCFV-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C=O)C1
- CAS DataBase Reference
- 59379-02-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-51-36-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B6091
- Product name
- (±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
- Packaging
- 1G
- Price
- $91
- Updated
- 2025/07/31
- Product number
- B6091
- Product name
- (±)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxaldehyde
- Packaging
- 5G
- Price
- $364
- Updated
- 2025/07/31
- Product number
- B665875
- Product name
- 1-Boc-pyrrolidine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 409037
- Product name
- 1-Boc-pyrrolidine-3-carboxaldehyde
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- 265685
- Product name
- 1-Boc-3-formyl-pyrrolidine
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
1-Boc-3-pyrrolidinecarbaldehyde Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow oil
Uses
1-Boc-pyrrolidine-3-carboxaldehyde is used in the preparation of tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.
Synthesis
114214-69-6
59379-02-1
General procedure for the synthesis of 1-Boc-3-pyrrolidinecarboxaldehyde from 1-Boc-3-hydroxymethylpyrrolidine: 1 kg of N-Boc-pyrrolidine-3-methanol was dissolved in 5 liters of dimethylsulfoxide (DMSO), and 2.14 kg of manganese dioxide was slowly added at room temperature. The reaction mixture was stirred at room temperature for about 24 hours to ensure complete reaction. Upon completion of the reaction, insoluble solids were removed by filtration and the filtrate was concentrated by rotary evaporator to remove solvent. Ultimately, N-Boc-pyrrolidine-3-carbaldehyde (920 g) was purified by reduced pressure distillation in 93% yield.
References
[1] Patent: CN106588738, 2017, A. Location in patent: Paragraph 0036; 0041; 0042; 0046; 0047; 0048
[2] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 131
[3] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 159
[4] Synlett, 2017, vol. 28, # 4, p. 425 - 428
[5] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 13, p. 1785 - 1789
1-Boc-3-pyrrolidinecarbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-3-pyrrolidinecarbaldehyde manufacturers
- Product
- 1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 1-Boc-3-pyrrolidinecarbaldehyde 59379-02-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24