YAP-TEAD Inhibitor 1

Product Name: YAP-TEAD Inhibitor 1
CAS No.: 1659305-78-8
Chemical Name: YAP-TEAD Inhibitor 1
Synonyms: YAP-TEAD-IN-1;Y413924] YAP-TEAD;YAP-TEAD Inhibitor 1;L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide
CBNumber: CB24656621
Molecular Formula: C93H144ClN23O21S2
Formula Weight: 2019.86
MOL File: 1659305-78-8.mol

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YAP-TEAD Inhibitor 1 Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 4.45±0.10(Predicted)
Water Solubility: Water: 40 mg/mL (19.80 mM);

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Hazard and Precautionary Statements (GHS)

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YAP-TEAD Inhibitor 1 Chemical Properties,Usage,Production

Biological Activity

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

References

[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998. [2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732.

YAP-TEAD Inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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YAP-TEAD Inhibitor 1 Suppliers

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1659305-78-8, YAP-TEAD Inhibitor 1Related Search:

YAP-TEAD Inhibitor 1

YAP-TEAD-IN-1

L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide

Y413924] YAP-TEAD

1659305-78-8

C93H144ClN23O21S2