ChemicalBook > CAS DataBase List > YAP-TEAD Inhibitor 1
YAP-TEAD Inhibitor 1
- Product Name
- YAP-TEAD Inhibitor 1
- CAS No.
- 1659305-78-8
- Chemical Name
- YAP-TEAD Inhibitor 1
- Synonyms
- YAP-TEAD-IN-1;Y413924] YAP-TEAD;YAP-TEAD Inhibitor 1;L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide
- CBNumber
- CB24656621
- Molecular Formula
- C93H144ClN23O21S2
- Formula Weight
- 2019.86
- MOL File
- 1659305-78-8.mol
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YAP-TEAD Inhibitor 1 Property
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 4.45±0.10(Predicted)
- Water Solubility
- Water: 40 mg/mL (19.80 mM);
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YAP-TEAD Inhibitor 1 Chemical Properties,Usage,Production
Biological Activity
YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].
References
[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998. [2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732.
YAP-TEAD Inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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YAP-TEAD Inhibitor 1 Suppliers
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
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- Advantage
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