PubChem ID: 397887
- Product Name
- PubChem ID: 397887
- CAS No.
- 308246-57-3
- Chemical Name
- PubChem ID: 397887
- Synonyms
- Mj-III-65;LMP744 HCl;PubChem ID: 397887;LMP744 hydrochloride;MJ-III65 hydrochloride;NSC706744 hydrochloride);LMP744/MJ-III65/NSC706744 hydrochloride;LMP744; LMP-744; LMP 744; MJ-III-65; NSC-706744;LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride;6-(3-((2-Hydroxyethyl)amino)propyl)-2,3-dimethoxy-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione hydrochloride
- CBNumber
- CB24840275
- Molecular Formula
- C24H25ClN2O7
- Formula Weight
- 488.92
- MOL File
- 308246-57-3.mol
PubChem ID: 397887 Property
- Melting point:
- 284-288 °C
- storage temp.
- Store at -20°C
- solubility
- DMSO : 5.56 mg/mL (11.37 mM)
- form
- Solid
- color
- Light brown to brown
N-Bromosuccinimide Price
- Product number
- CS-0086159
- Product name
- LMP744hydrochloride
- Purity
- 99.21%
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0086159
- Product name
- LMP744hydrochloride
- Purity
- 99.21%
- Packaging
- 5mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CS-0086159
- Product name
- LMP744hydrochloride
- Purity
- 99.21%
- Packaging
- 50mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- DC20275
- Product name
- LMP744
- Purity
- >98%
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- DC20275
- Product name
- LMP744
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1700
- Updated
- 2021/12/16
PubChem ID: 397887 Chemical Properties,Usage,Production
Uses
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
in vivo
LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].
| Animal Model: | Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1]. |
| Dosage: | 10, 25, or 50 mg/kg/week, 4 weeks |
| Administration: | I.V. push via tail vein |
| Result: | Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity. |
IC 50
Top1
References
[1] Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. DOI:10.1124/mol.104.003889
[2] Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 DOI:10.1124/mol.106.024372
PubChem ID: 397887 Preparation Products And Raw materials
Raw materials
Preparation Products
PubChem ID: 397887 Suppliers
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