ChemicalBook > CAS DataBase List > 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

Product Name
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
CAS No.
1198357-79-7
Chemical Name
3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
Synonyms
ETP 45658;ETP-45658, 10 mM in DMSO;3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol;3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol;Phenol, 3-[1-methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-;Inhibitor,PI3K,breast,DNA-PK,Mammalian target of Rapamycin,DNA-dependent protein kinase,mTOR,inhibit,Phosphoinositide 3-kinase,ETP-45658,cancer
CBNumber
CB24902630
Molecular Formula
C16H17N5O2
Formula Weight
311.34
MOL File
1198357-79-7.mol
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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
9.18±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
4702
Product name
ETP45658
Purity
≥98%(HPLC)
Packaging
10
Price
$205
Updated
2021/12/16
Tocris
Product number
4702
Product name
ETP45658
Purity
≥98%(HPLC)
Packaging
50
Price
$865
Updated
2021/12/16
TRC
Product number
E936915
Product name
ETP45658
Packaging
5mg
Price
$115
Updated
2021/12/16
TRC
Product number
E936915
Product name
ETP45658
Packaging
10mg
Price
$185
Updated
2021/12/16
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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Chemical Properties,Usage,Production

Uses

ETP 45658 is a potent and selective inhibitor of phosphoinositol 3-kinase and demonstrates mechanism of action in tumor cells, inhibitors of mTOR kinase as antiviral agents.

in vivo

ETP-45658 (22.7 mg/kg) decreases the level of phosphorylated Akt on serine 473 in the mammary ducts of transgenic mice[1].

IC 50

PI3Kα: 22.0 nM (IC50); PI3Kδ: 39.8 nM (IC50); PI3Kβ: 129.0 nM (IC50); PI3Kγ: 717.3 nM (IC50); DNA-PK: 70.6 nM (IC50); mTOR: 152.0 nM (IC50)

storage

Store at +4°C

3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol Suppliers

China 22 India 1 United Kingdom 1 United States 3 USA 1 Global 28
Shanghai YuanYe Biotechnology Co., Ltd.
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15076683720
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Shanghai Hongye Biotechnology Co. Ltd
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sales@glpbio.cn
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Absin Bioscience Inc.
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1198357-79-7, 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenolRelated Search:


  • 3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol
  • ETP 45658
  • 3-(1-Methyl-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol
  • Inhibitor,PI3K,breast,DNA-PK,Mammalian target of Rapamycin,DNA-dependent protein kinase,mTOR,inhibit,Phosphoinositide 3-kinase,ETP-45658,cancer
  • Phenol, 3-[1-methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-
  • ETP-45658, 10 mM in DMSO
  • 1198357-79-7