3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
- Product Name
- 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
- CAS No.
- 1679330-37-0
- Chemical Name
- 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
- Synonyms
- AZ Dyrk1B 33;AZ-Dyrk1B-33, 10 mM in DMSO;1-Benzyl-3-(2-methylpyrimidin-4-yl)-1H-pyrrolo[2,3-c];3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2;1-Benzyl-3-(2-methylpyrimidin-4-yl)-1H-pyrrolo[2,3-c]pyridine;3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine;1H-Pyrrolo[2,3-c]pyridine, 3-(2-methyl-4-pyrimidinyl)-1-(phenylmethyl)-;Dual specificity tyrosine regulated kinase,kinase,syndrome,mechanism,cells,resistance,stress,inhibit,Inhibitor,metabolic,response,undergoing,DYRK,Mirk-related,AZDyrk1B33,Minibrain-related,Dyrk1B,AZ Dyrk1B 33,Dual specificity tyrosine phosphorylation regulated kinase,AZ-Dyrk-1B-33,osteosarcoma
- CBNumber
- CB24902771
- Molecular Formula
- C19H16N4
- Formula Weight
- 300.36
- MOL File
- 1679330-37-0.mol
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine Property
- Boiling point:
- 541.2±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 6.79±0.30(Predicted)
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5632
- Product name
- AZDyrk1B33
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $296
- Updated
- 2021/12/16
- Product number
- M337923
- Product name
- 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
- Packaging
- 2.5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0065849
- Product name
- AZ-Dyrk1B-33
- Purity
- ≥99.0%
- Packaging
- 5mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-0065849
- Product name
- AZ-Dyrk1B-33
- Purity
- ≥99.0%
- Packaging
- 1mg
- Price
- $180
- Updated
- 2021/12/16
3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine Chemical Properties,Usage,Production
Uses
4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridyl)-2H-pyrazolo[3,4-b]pyridine is a potential Dyrk1B kinase inhibitor and used to investigate resistance mechanism related to stress response in cells.
Biological Activity
Potent and selective Dyrk1B kinase inhibitor th at increased the number of incretin-expressing cells in diabetic mice.
AZ Dyrk1B 33 is a potent and selective Dyrk1B kinase (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor. AZ Dyrk1B 33 potently increases the numbers of neurogenin 3-expressing enteroendocrine progenitors, Gip-expressing K-cells, and Glp-1-expressing L-cells in zebrafish and diabetic mice. It decreases glucose levels in both larval and juvenile zebrafish.
storage
Store at +4°C