N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine

Product Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
CAS No.: 339303-87-6
Chemical Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Synonyms: UCLA P130 2;GP130 receptor agonist-1;GP130 receptor agonist-1, 10 mM in DMSO;N-(4-Fluorophenyl)-4-phenyl-2-thiazolami;N-(4-Fluorophenyl)-4-phenylthiazol-2-amine;N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine;2-Thiazolamine, N-(4-fluorophenyl)-4-phenyl-;GP130 receptor agonist-1,neuroprotective,Inhibitor,penetrant,NMDA,inhibit,GP-130 receptor agonist-1,brain,Interleukin Related,GP130 receptor agonist1,GP130,GP130 receptor agonist 1
CBNumber: CB24902807
Molecular Formula: C15H11FN2S
Formula Weight: 270.32
MOL File: 339303-87-6.mol

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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: F632443
Product name: N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine
Packaging: 1mg
Price: $75
Updated: 2021/12/16

TRC

Product number: F632443
Product name: N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine
Packaging: 2.5mg
Price: $155
Updated: 2021/12/16

CSNpharm

Product number: CSN23176
Product name: UCLAGP1302
Packaging: 50mg
Price: $455
Updated: 2021/12/16

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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Chemical Properties,Usage,Production

Uses

N-(4-Fluorophenyl)-4-phenyl-1,3-thiazol-2-amine is a gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant.

in vivo

For GP130 receptor agonist-1 (Compound 2), mice are dosed orally at 10 or 30 mg/kg, or injected subcutaneously (SQ) at 10 mg/kg, and euthanized after 1, 2, 4, 6, and 8 h post dose. At 2 h after SQ delivery at 10 mg/kg the brain Cmax is 161 ng/g while dosing at 30 mg/kg orally, results in the brain Cmax of 156 ng/g (0.57 μM). The brain to plasma ratio for 2 is ～4:1 for oral 30 mg/kg and ～7.5:1 for 10 mg/kg SQ injection^[1].

storage

Store at +4°C

N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine Suppliers

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339303-87-6, N-(4-Fluorophenyl)-4-phenyl-2-thiazolamineRelated Search:

N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine

2-Thiazolamine, N-(4-fluorophenyl)-4-phenyl-

GP130 receptor agonist-1

N-(4-Fluorophenyl)-4-phenyl-2-thiazolami

N-(4-Fluorophenyl)-4-phenylthiazol-2-amine

GP130 receptor agonist-1,neuroprotective,Inhibitor,penetrant,NMDA,inhibit,GP-130 receptor agonist-1,brain,Interleukin Related,GP130 receptor agonist1,GP130,GP130 receptor agonist 1

UCLA P130 2

GP130 receptor agonist-1, 10 mM in DMSO

339303-87-6