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ABT-418 HYDROCHLORIDE

Product Name
ABT-418 HYDROCHLORIDE
CAS No.
147388-83-8
Chemical Name
ABT-418 HYDROCHLORIDE
Synonyms
ABT-418 HCl;ABT-418 HYDROCHLORIDE;ABT418 hydrochloride,ABT 418 hydrochloride;(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl;3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride;3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride
CBNumber
CB2497879
Molecular Formula
C9H14N2O.ClH
Formula Weight
202.684
MOL File
147388-83-8.mol
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ABT-418 HYDROCHLORIDE Property

storage temp. 
-20°C
solubility 
H2O: 15 mg/mL, soluble
form 
solid
color 
white to off-white
Water Solubility 
H2O: soluble 15mg/mL
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-28-36/37-45-7/9
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A6476
Product name
ABT-418 hydrochloride
Purity
powder, ≥98% (HPLC)
Packaging
5mg
Price
$234.65
Updated
2025/07/31
Sigma-Aldrich
Product number
A6476
Product name
ABT-418 hydrochloride
Purity
powder, ≥98% (HPLC)
Packaging
25mg
Price
$678
Updated
2025/07/31
TRC
Product number
A112610
Product name
ABT-418 hydrochloride
Packaging
5mg
Price
$165
Updated
2021/12/16
TRC
Product number
A112610
Product name
ABT-418 hydrochloride
Packaging
10mg
Price
$265
Updated
2021/12/16
ChemScene
Product number
CS-0025191
Product name
ABT-418 hydrochloride
Purity
99.53%
Packaging
5mg
Price
$120
Updated
2021/12/16
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ABT-418 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam.2 Reduces distractibility in a primate model3 and may have relevance in attention deficit hyperactivity disorder4. Improves cognition in Alzheimer’s disease patients.5

Uses

ABT-418 Hydrochloride is a neuronal nicotinic acetylcholine receptor agonist or activator which can be synthesized from L-proline.

in vivo

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2].

Animal Model:Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]
Dosage:0.6 mg/kg
Administration:Intraperitoneal injection; once daily; for two weeks
Result:Effectively improved spatial memory.

References

[1] R L PAPKE. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418.[J]. British Journal of Pharmacology, 1997, 120 3: 429-438. DOI:10.1038/sj.bjp.0700930
[2] J D BRIONI. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 1: 353-361.
[3] M A PRENDERGAST. Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys.[J]. Psychopharmacology, 1998, 136 1: 50-58. DOI:10.1007/s002130050538
[4] J BIEDERMAN  T S. Non-stimulant treatments for ADHD.[J]. European Child & Adolescent Psychiatry, 2000, 9 Suppl 1: I51-9. DOI:10.1007/s007870070019
[5] A POTTER. Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer’s disease.[J]. Psychopharmacology, 1999, 142 4: 334-342. DOI:10.1007/s002130050897

ABT-418 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT-418 HYDROCHLORIDE Suppliers

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147388-83-8, ABT-418 HYDROCHLORIDERelated Search:

REVERSINE 1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Ginkgolide B N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

  • ABT-418 HCl
  • (S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl
  • ABT-418 HYDROCHLORIDE
  • 3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride
  • ABT418 hydrochloride,ABT 418 hydrochloride
  • 3-Methyl-5-[(2S)-1-Methyl-2-Pyrrolidinyl]-1,2-Oxazole Hydrochloride
  • 147388-83-8