ERYTHROMYCIN GLUCEPTATE (200 MG) Property

Melting point:

95-140°

solubility 

DMSO (Sparingly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Safety

HS Code 

2941500000

Hazard and Precautionary Statements (GHS)

ERYTHROMYCIN GLUCEPTATE (200 MG) Chemical Properties,Usage,Production

Originator

Ilotycin Gluceptate,Dista,US,1954

Uses

Antibacterial.

Uses

Erythromycin Glucoheptonate is a derivative of Erythromycin (E649950), an antibiotic.

Manufacturing Process

A solution of 10 grams of d-glucoheptonic acid lactone in 50 ml of distilled water is warmed on a steam bath for about 2 hours to hydrolyze the lactone to the acid. The mixture is cooled and 100 ml of 95% ethanol are added. To the solution of glucoheptonic acid are added about 37 grams of erythromycin and the volume of the reaction mixture is brought to 200 ml by the addition of 95% ethanol. The reaction mixture is stirred for about 2 hours and is filtered through a porcelain filter candle of porosity 02. To provide a sterile product, aseptic technique is used throughout the remainder of the procedure. To the filtered solution are added slowly and with stirring about 1,200 ml of anhydrous ether, to cause precipitation of erythromycin d-glucoheptonate and to keep in solution any excess of unreacted erythromycin. The precipitated erythromycin salt is removed by filtration through a sintered glass funnel, is washed with anhydrous ether and is dried in vacuo. Erythromycin dglucoheptonate melts over a range of about 95° to 140°C.

brand name

Ilotycin (Dista).

Therapeutic Function

Antibacterial