ChemicalBook > CAS DataBase List > 2-ETHOXY-MALONIC ACID DIETHYL ESTER

2-ETHOXY-MALONIC ACID DIETHYL ESTER

Uses

Product Name: 2-ETHOXY-MALONIC ACID DIETHYL ESTER
CAS No.: 37555-99-0
Chemical Name: 2-ETHOXY-MALONIC ACID DIETHYL ESTER
Synonyms: Diethyl ethoxymalonate;diethyl 2-ethoxymalonate;2-Hydroxydiethyl Malonate;Diethyl ethoxypropanedioate;Diethyl 2-ethoxy-malonic acid;diethyl 2-ethoxypropanedioate;1,3-diethyl 2-ethoxypropanedioate;ethoxy-malonic acid diethyl ester;2-ETHOXY-MALONIC ACID DIETHYL ESTER;Ethoxypropanedioic acid diethyl ester
CBNumber: CB2663320
Molecular Formula: C9H16O5
Formula Weight: 204.22
MOL File: 37555-99-0.mol

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2-ETHOXY-MALONIC ACID DIETHYL ESTER Property

Boiling point:: 261℃
Density: 1.070
Flash point:: 108℃
storage temp.: Sealed in dry,Room Temperature
pka: 13.29±0.46(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: W5840
Product name: Ethoxy-malonicaciddiethylester
Packaging: 5g
Price: $303
Updated: 2021/12/16

Matrix Scientific

Product number: 073942
Product name: Ethoxymalonic acid diethyl ester
Purity: 95+%
Packaging: 1g
Price: $416
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0087307
Product name: 2-ETHOXY-MALONIC ACID DIETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $1034.88
Updated: 2021/12/16

Matrix Scientific

Product number: 073942
Product name: Ethoxymalonic acid diethyl ester
Purity: 95+%
Packaging: 5g
Price: $1197
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0087307
Product name: 2-ETHOXY-MALONIC ACID DIETHYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $2067.45
Updated: 2021/12/16

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2-ETHOXY-MALONIC ACID DIETHYL ESTER Chemical Properties,Usage,Production

Uses

Diethyl ethoxymalonate is a hydroxyl malonic acid ester and a commonly used reagent in organic synthesis.

Synthesis

817-95-8

95-92-1

37555-99-0

Example 1: Scheme 4 Preparation of diethyl 2-ethoxy-malonate A mixture of diethyl oxalate (39.23 ml, 1.12 eq.) and ethyl 2-ethoxyacetate (34.95 ml, 1 eq.) was added dropwise to a slurry of sodium ethanolate (18.64 g, 1.07 eq.) in toluene (100 ml) at 45-50 °C. After the dropwise addition was completed, the reaction mixture was heated to 70-80°C and maintained for 2 hours. After completion of the reaction, the mixture was cooled and poured into 70 ml of 14% hydrochloric acid solution. The resulting mixture was extracted with ethyl acetate (EA), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 55.86 g (93.7% yield) of the target product diethyl 2-ethoxy-malonate.

References

[1] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 47-48

2-ETHOXY-MALONIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials

Ethanol Sodium ethoxide Carbon tetrachloride Bromine Diethyl malonate

Preparation Products

Lomefloxacin

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37555-99-0, 2-ETHOXY-MALONIC ACID DIETHYL ESTERRelated Search:

TRIPHENYLETHOXYSILANE CHLOROMETHYLDIMETHYLETHOXYSILANE ETHOXYTRIETHYLSILANE Ethoxymethylenemalononitrile Ethoxyacetic acid Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate ETHOXY-IMINO-ACETIC ACID ETHYL ESTER BISPHENOL A ETHOXYLATE DIMETHACRYLATE Triethyl orthoformate Diethyl malonate Diethyl ethoxymethylenemalonate TARTRONIC ACID Ethyl (triphenylphosphoranylidene)acetate Ethyl 2-(triphenylphosphoranylidene)propionate DIMETHYL METHOXYMALONATE 2-ETHOXY-MALONIC ACID DIETHYL ESTER ETHYL (S)-(-)-2-METHOXYPROPIONATE DIETHYL 2-HYDROXYMALONATE

2-ETHOXY-MALONIC ACID DIETHYL ESTER

ethoxy-malonic acid diethyl ester

diethyl 2-ethoxymalonate

Diethyl ethoxymalonate

Ethoxypropanedioic acid diethyl ester

1,3-diethyl 2-ethoxypropanedioate

2-Hydroxydiethyl Malonate

Propanedioic acid, 2-ethoxy-, 1,3-diethyl ester

Diethyl ethoxypropanedioate

diethyl 2-ethoxypropanedioate

Diethyl 2-ethoxy-malonic acid

37555-99-0