CAY10464

Product Name: CAY10464
CAS No.: 688348-37-0
Chemical Name: CAY10464
Synonyms: CAY10464;CAY10464 Exclusive;1,3-dichloro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene;1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene;Benzene, 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-
CBNumber: CB2672568
Molecular Formula: C15H12Cl2O
Formula Weight: 279.16
MOL File: 688348-37-0.mol

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CAY10464 Property

Boiling point:: 409.3±45.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .5 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10006545
Product name: CAY10464
Purity: ≥98%
Packaging: 10mg
Price: $22
Updated: 2024/03/01

Cayman Chemical

Product number: 10006545
Product name: CAY10464
Purity: ≥98%
Packaging: 25mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 10006545
Product name: CAY10464
Purity: ≥98%
Packaging: 50mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 10006545
Product name: CAY10464
Purity: ≥98%
Packaging: 100mg
Price: $167
Updated: 2024/03/01

AK Scientific

Product number: 1122AH
Product name: 1,3-Dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
Packaging: 10mg
Price: $122
Updated: 2021/12/16

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CAY10464 Chemical Properties,Usage,Production

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar. CAY10464 is a potent and selective AhR antagonist, with a K_i of 1.4 nM when tested in rabbit liver cytosol preparations. It is inactive as an estrogen receptor ligands even at 100 μM.

Uses

CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM[1].

References

[1] Philippe de Medina, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194
[2] Emad Naem,et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. DOI:10.1016/j.lfs.2012.06.002

CAY10464 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10464 Suppliers

China 26 United States 2 USA 1 Global 29

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688348-37-0, CAY10464Related Search:

6,8-DICHLORO-3(4'-METHOXYPHENYL)-4-METHYLCOUMARIN 6,8-DICHLORO-3(3',4'-DIMETHOXYPHENYL)-4-METHYLCOUMARIN 6,8-DICHLORO-3(4'-METHOXYPHENYL)-4-PHENYLCOUMARIN CAY10464 6,8-DICHLORO-4-(4'-HYDROXYPHENYL)-3-(4'-METHOXYPHENYL)COUMARIN

CAY10464

1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene

CAY10464 Exclusive

1,3-dichloro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene

Benzene, 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-

688348-37-0