5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

Product Name: 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
CAS No.: 3757-53-7
Chemical Name: 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
Synonyms: 5-Methylpyrrole-2-Carboxylic Acid;5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID;1H-Pyrrole-2-carboxylic acid, 5-methyl-
CBNumber: CB2803461
Molecular Formula: C6H7NO2
Formula Weight: 125.13
MOL File: 3757-53-7.mol

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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Property

Melting point:: 137-138 °C
Boiling point:: 326.3±22.0 °C(Predicted)
Density: 1.295±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.73±0.10(Predicted)
Appearance: Light yellow to light brown Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: M339113
Product name: 5-Methylpyrrole-2-carboxylicAcid
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR962602
Product name: 5-Methyl-1H-pyrrole-2-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0299038
Product name: 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $498.59
Updated: 2021/12/16

Apolloscientific

Product number: OR962602
Product name: 5-Methyl-1H-pyrrole-2-carboxylicacid
Purity: 98%
Packaging: 5g
Price: $565
Updated: 2021/12/16

AK Scientific

Product number: 4808AB
Product name: 5-Methyl-1H-pyrrole-2-carboxylicacid
Packaging: 25g
Price: $1092
Updated: 2021/12/16

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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

5-Methylpyrrole-2-carboxylic Acid is a useful reactant in preparation and biological evaluation of coumarin-carboxylic acids as inhibitors of gyrase B.

Synthesis

3284-51-3

3757-53-7

Ethyl 5-methyl-1H-pyrrole-2-carboxylate (400 mg, 2.61 mmol) was dissolved in a mixed solvent of dioxane/water/ethanol (10 mL/1 mL/2 mL) with reference to the method of Curran, T.; Keaney, M. (J. Org. Chem., 61(25), 1996, 9068-9069). Sodium hydroxide (520 mg, 13 mmol) was added and the reaction was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. The crude product was dissolved in water and extracted with dichloromethane (DCM). The aqueous phase was adjusted to pH 1 with 1N hydrochloric acid and the organic and aqueous phases were separated. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude 5-methyl-1H-pyrrole-2-carboxylic acid, which can be used in the next reaction without further purification. Yield: quantitative; LCMS (retention time): 2.51 min (Method D); MS (ES+) m/z: 126.03.

References

[1] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 57-58
[2] Tetrahedron Letters, 2003, vol. 44, # 1, p. 61 - 63
[3] Chemistry - A European Journal, 2017, vol. 23, # 14, p. 3300 - 3320
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 553 - 557
[5] Annali di Chimica (Rome, Italy), 1956, vol. 46, p. 847,854

5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID Suppliers

China 70 China Hong Kong 1 Germany 1 India 1 United Kingdom 1 United States 5 Global 79

Eurolabs Limited

Tel: --
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Country: United Kingdom
ProdList: 6309
Advantage: 46

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View Lastest Price from 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Methyl-1H-pyrrole-2-carboxylic acid 3757-53-7
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-14

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Methylpyrrole-2-Carboxylic Acid 3757-53-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 3757-53-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

3757-53-7, 5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACIDRelated Search:

5-Methyl-1H-pyrazole-3-carboxylic acid ETHYL 3,4,5-TRIMETHYLPYRROLE-2-CARBOXYLATE 4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid Ethyl 2,4-dimethyl-5-(ethoxycarbonyl)-3-pyrrolepropionate 3-ACETYL-2,4-DIMETHYL-5-CARBETHOXYPYRROLE ETHYL 4-ETHYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLATE Pyrroloquinoline quinone Diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate Ethyl 3,5-dimethyl-1H-pyrrole-2-carboxylate TERT-BUTYL 3,4,5-TRIMETHYL-2-PYRROLECARBOXYLATE ETHYL 4-FORMYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLATE 5-FORMYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER METHYL 5-(BENZYLOXYCARBONYL)-2,4-DIMETHYL-3-PYRROLEPROPIONATE ethyl 4-(2-methoxycarbonylethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate TERT-BUTYL 4-ACETYL-3,5-DIMETHYL-2-PYRROLECARBOXYLATE 4-(2-CARBOXYETHYL)-3,5-DIMETHYLPYRROLE-2-CARBOXYLIC ACID, ETHYL ETHER 4-ACETYL-3,5-DIMETHYL-1H-PYRROLE-2-CARBOXYLIC ACID 5-BROMOMETHYL-3-METHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID DIETHYL ESTER

1H-Pyrrole-2-carboxylic acid, 5-methyl-

5-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID

5-Methylpyrrole-2-Carboxylic Acid

3757-53-7