1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI)
- Product Name
- 1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI)
- CAS No.
- 870153-29-0
- Chemical Name
- 1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI)
- Synonyms
- PF-00835231;PF835231;PF 835231;PF-835231;PF-00835231 ，S9731;PF-00835231 (PF-835231);PF-00835231, 10 mM in DMSO;PF00835231(SARS-CoV-2 inhibitor 5h);Inhibitor,SARS coronavirus,PF00835231,PF-00835231,SARS CoV-2,COVID-19,SARS-CoV,SARS CoV-1,3CLpro,inhibit,PF 00835231;N-((S)-1-(((S)-4-Hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide
- CBNumber
- CB28129239
- Molecular Formula
- C24H32N4O6
- Formula Weight
- 472.53
- MOL File
- 870153-29-0.mol
1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI) Property
- Boiling point:
- 865.8±65.0 °C(Predicted)
- Density
- 1.264±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (529.07 mM; Need ultrasonic)
- form
- A solid
- pka
- 12.76±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3314
- Product name
- PF-00835231
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $71.1
- Updated
- 2025/07/31
- Product number
- SML3314
- Product name
- PF-00835231
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $288
- Updated
- 2025/07/31
- Product number
- 027571
- Product name
- PF00835231
- Packaging
- 001
- Price
- $1900
- Updated
- 2021/12/16
1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI) Chemical Properties,Usage,Production
Uses
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19. PF-00835231 can inhibit cell infections and also suppress infections in animal models[1][2][3].
Definition
ChEBI: PF-00835231 is a primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity. It has a role as an anticoronaviral agent, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and a drug metabolite. It is an aromatic ether, a L-leucine derivative, an indolecarboxamide, a member of pyrrolidin-2-ones, a secondary carboxamide and a primary alcohol.
Biological Activity
Potent and selective corona virus hCoV, SARS CoV-1 & CoV-2 main protease (Mpro; 3CLpro) substrate site Cys145 covalent inhibitor with low host cytotoxicity.
in vivo
PF-00835231 reduces the number of multifocal lung lesions and lung viral load in the SARS-CoV-MA15 infected BALB/c mouse model, being effective both early and late in the viral infection[3].
IC 50
HIV-1; HRV3C: 2.79 μM (IC50)
References
[1] Robert L Hoffman, et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725-12747. DOI:10.1021/acs.jmedchem.0c01063
[2] de Vries M, et al. A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19. bioRxiv [Preprint]. 2021 Feb 19:2020.08.28.272880. DOI:10.1101/2020.08.28.272880
[3] Wujun Chen, wt al. Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection. Front Pharmacol. 2022 Nov 11:13:1035969. DOI:10.3389/fphar.2022.1035969
1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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