ChemicalBook > CAS DataBase List > 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-
4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-
- Product Name
- 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-
- CAS No.
- 2314467-59-7
- Chemical Name
- 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-
- Synonyms
- OUN67600;TRPV4 agonist-1 free base;TRPV4 agonist-1 free base, 10 mM in DMSO;8-Fluoro-3-(4-(4-fluorophenoxy)phenyl)-2-(4-methylpiperazin-1-yl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-;8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one;Transient receptor potential channels,TRP Channel,Inhibitor,TRPV4 agonist1 free base,inhibit,TRPV4 agonist 1 free base,TRPV-4 agonist-1 free base,TRPV4 agonist-1
- CBNumber
- CB28231831
- Molecular Formula
- C25H22F2N4O2
- Formula Weight
- 448.46
- MOL File
- 2314467-59-7.mol
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4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Property
- Boiling point:
- 580.6±60.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 83.33 mg/mL (185.81 mM; Need ultrasonic)
- pka
- 7.16±0.42(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0084969
- Product name
- TRPV4agonist-1freebase
- Purity
- 99.81%
- Packaging
- 25mg
- Price
- $650
- Updated
- 2021/12/16
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4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Chemical Properties,Usage,Production
Uses
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
References
[1] Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28. DOI:10.1021/acs.jmedchem.8b01615
4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)- Suppliers
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