AES-350

Product Name: AES-350
CAS No.: 847249-57-4
Chemical Name: AES-350
Synonyms: AES-350;4-(4-tert-butylbenzamido)-N-hydroxybenzamide;4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide;Benzamide, 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-;Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,inhibit,AES350,HDAC
CBNumber: CB28571007
Molecular Formula: C18H20N2O3
Formula Weight: 312.36
MOL File: 847249-57-4.mol

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AES-350 Property

Density: 1.218±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 1 mg/ml
form: A crystalline solid
pka: 8.93±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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AES-350 Chemical Properties,Usage,Production

Uses

AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].

in vivo

AES-350 (oral gavage; 20 mg/kg; single dose) exhibits a relative good pharmacokinetic (PK) properties in CD-1 mice. The single dose oral bioavailability (F%) of 51 is 19.8%. In comparison, the reported F% for SAHA in mice is significantly lower (8%)^[1].

IC 50

HDAC6: 24.4 nM (IC₅₀); HDAC3: 187 nM (IC₅₀); HDAC11: 245 nM (IC₅₀)

References

[1] Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. DOI:10.1021/acsmedchemlett.9b00471

AES-350 Preparation Products And Raw materials

Raw materials

Preparation Products

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AES-350 Suppliers

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847249-57-4, AES-350Related Search:

AES-350

Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,inhibit,AES350,HDAC

Benzamide, 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-

4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide

4-(4-tert-butylbenzamido)-N-hydroxybenzamide

847249-57-4