AES-350

Product Name: AES-350
CAS No.: 847249-57-4
Chemical Name: AES-350
Synonyms: AES-350;4-(4-tert-butylbenzamido)-N-hydroxybenzamide;4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide;Benzamide, 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-;Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,inhibit,AES350,HDAC
CBNumber: CB28571007
Molecular Formula: C18H20N2O3
Formula Weight: 312.36
MOL File: 847249-57-4.mol

More

Less

AES-350 Property

Density: 1.218±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 1 mg/ml
form: A crystalline solid
pka: 8.93±0.10(Predicted)
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

AES-350 Chemical Properties,Usage,Production

Uses

AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].

in vivo

AES-350 (oral gavage; 20 mg/kg; single dose) exhibits a relative good pharmacokinetic (PK) properties in CD-1 mice. The single dose oral bioavailability (F%) of 51 is 19.8%. In comparison, the reported F% for SAHA in mice is significantly lower (8%)^[1].

IC 50

HDAC6: 24.4 nM (IC₅₀); HDAC3: 187 nM (IC₅₀); HDAC11: 245 nM (IC₅₀)

References

[1] Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. DOI:10.1021/acsmedchemlett.9b00471

AES-350 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AES-350 Suppliers

China 23 United States 6 Global 29

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2390
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12476
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shandong Territorial sea Biological Technology Co., LTD

Tel: 15092083467
Email: 18660263263@163.com
Country: China
ProdList: 2807
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4798
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 133-3998-5473 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 4991
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 7977
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Guangzhou Huiheng Biotechnology Co., Ltd.

Tel: 18675945663
Country: CHINA
ProdList: 126
Advantage: 58

Chongqing Aoyi Biotechnology Co., Ltd.

Tel: 13102311730,18585291730
Country: CHINA
ProdList: 140
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

847249-57-4, AES-350Related Search:

AES-350

Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,inhibit,AES350,HDAC

Benzamide, 4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-

4-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-hydroxy-benzamide

4-(4-tert-butylbenzamido)-N-hydroxybenzamide

847249-57-4