Dalfopristin
- Product Name
- Dalfopristin
- CAS No.
- 112362-50-2
- Chemical Name
- Dalfopristin
- Synonyms
- RP 54476;Dalfopristin;Dalfopristin Mesylate;Dalfopristin (RP54476);Dalfopristin (as mesylate);Dalfopristin, 10 mM in DMSO;RP-54476,RP 54476,Inhibitor,Dalfopristin,Antibiotic,Bacterial,inhibit;(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadi;(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(DiethylaMino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-diMethyl-3-(1-Methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetr;(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
- CBNumber
- CB31075198
- Molecular Formula
- C34H50N4O9S
- Formula Weight
- 690.85
- MOL File
- 112362-50-2.mol
Dalfopristin Property
- Melting point:
- ~150°
- Boiling point:
- 940.5±65.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:113.0(Max Conc. mg/mL);163.57(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);144.75(Max Conc. mM) - form
- Solid
- pka
- 13.18±0.70(Predicted)
- color
- White to yellow
Safety
- Hazardous Substances Data
- 112362-50-2(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 19762
- Product name
- Dalfopristin (mesylate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- 19762
- Product name
- Dalfopristin (mesylate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $1091
- Updated
- 2024/03/01
- Product number
- CS-6142
- Product name
- Dalfopristin
- Purity
- 98.34%
- Packaging
- 1mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- C5482
- Product name
- Dalfopristin(mesylate)
- Packaging
- 1mg
- Price
- $381
- Updated
- 2021/12/16
- Product number
- CS-6142
- Product name
- Dalfopristin
- Purity
- 98.34%
- Packaging
- 5mg
- Price
- $1032
- Updated
- 2021/12/16
Dalfopristin Chemical Properties,Usage,Production
Uses
A Viiginiamycin M1 (V672810) derivative. A streptogramin antibiotic used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.
Uses
Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Uses
Dalfopristin is a semi-synthetic analogue of ostreogrycin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogrycin, followed by oxidation to the sulfone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Definition
ChEBI: Dalfopristin is a macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium. It has a role as an antibacterial drug and a protein synthesis inhibitor. It is a macrolide, a member of 1,3-oxazoles, a cyclic ketone, an enamide, a secondary alcohol, a secondary carboxamide, a tertiary carboxamide, a sulfone, a tertiary amino compound, a carboxylic ester and a macrolide antibiotic. It is functionally related to a pristinamycin IIA.
in vivo
Dalfopristin (12 mg/kg/day, i.v., 7 days) shows no effects on hepatic cytochrome P-450 metabolite complexes in rats[2].
Dalfopristin Preparation Products And Raw materials
Raw materials
Preparation Products
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