ChemicalBook > CAS DataBase List > A 33

A 33

Product Name: A 33
CAS No.: 915082-52-9
Chemical Name: A 33
Synonyms: A-33;PDE4B-IN-2;PDE4B-IN-2, 10 mM in DMSO;Benzeneacetic acid, 4-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-;2-(4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid
CBNumber: CB31124771
Molecular Formula: C19H18ClN3O2S
Formula Weight: 387.88
MOL File: 915082-52-9.mol

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A 33 Property

storage temp.: Store at -20°C
solubility: 38.7mg/ml in DMSO
form: Solid
color: White to off-white
InChI: InChI=1S/C19H18ClN3O2S/c1-3-14-11(2)21-19(15-8-9-16(20)26-15)23-18(14)22-13-6-4-12(5-7-13)10-17(24)25/h4-9H,3,10H2,1-2H3,(H,24,25)(H,21,22,23)
InChIKey: FDVSPBLZPJMXFV-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=CC=C(NC2C(CC)=C(C)N=C(C3SC(Cl)=CC=3)N=2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2121
Product name: A-33
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2121
Product name: A-33
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $414.2
Updated: 2025/07/31

Tocris

Product number: 6313
Product name: A33
Purity: ≥98%(HPLC)
Packaging: 10
Price: $169
Updated: 2021/12/16

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A 33 Chemical Properties,Usage,Production

Uses

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects[1].

Biochem/physiol Actions

A-33 (A33) is a potent and selective catalytic site-targeting PDE4B inhibitor (IC50 = 15 nM/PDE4B vs. 1.7 μM/PDE4D) that effectively prevents PDE4B-medicated cellular cAMP hydrolysis (150%/320% increased cAMP level with 100 nM/1 μM A-33 pre-treament in murine hippocampal HT-22 cells following 10 nM isoproterenol stimulation) in vitro and inhibits LPS-induced TNF-α production in mice in vivo (ID50 = 14 mg/kg p.o.). When administered via intraperitoneal injection, A-33 improves cognitive function in a rat model of traumatic brain injury (0.3 mg/kg i.p.) and exhibits antidepressant property in mice (0.3-1 mg/kg i.p.) in vivo.

in vivo

PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a C_max of 8.7 μg/mL and an AUC of 52.3 μg h/mL in mice^[1].

IC 50

PDE4B: 15 nM (IC₅₀); PDE4D: 1.7 μM (IC₅₀)

storage

Store at -20°C

References

[1] Kenji Naganuma, et al. Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3174-6. DOI:10.1016/j.bmcl.2009.04.121

A 33 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 33 Suppliers

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915082-52-9, A 33Related Search:

A-33

Benzeneacetic acid, 4-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-

PDE4B-IN-2

2-(4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid

PDE4B-IN-2, 10 mM in DMSO

915082-52-9