4-Formylphenoxyacetic acid

Product Name: 4-Formylphenoxyacetic acid
CAS No.: 22042-71-3
Chemical Name: 4-Formylphenoxyacetic acid
Synonyms: 4-Formyl-PAA;AKOS B004256;AKOS AU36-M42;ASISCHEM R21550;4-FORMYL-PAA LINKER;4-FORMYLPHENOXYACETIC ACID;P-FORMYLPHENOXYACETIC ACID;(4-formylphenoxy)-aceticaci;4-FormylphenoxyaceticAcid>2-(4-formylphenoxy)aceticaci
CBNumber: CB3114243
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 22042-71-3.mol

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4-Formylphenoxyacetic acid Property

Melting point:: 193-196 °C
Boiling point:: 272.96°C (rough estimate)
Density: 1.2933 (rough estimate)
refractive index: 1.4500 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in hot methanol within almost transparency.
form: Crystalline Powder
pka: 3.04±0.10(Predicted)
color: Beige
Sensitive: Air Sensitive
BRN: 779885
InChI: InChI=1S/C9H8O4/c10-5-7-1-3-8(4-2-7)13-6-9(11)12/h1-5H,6H2,(H,11,12)
InChIKey: OYNIIKHNXNPSAG-UHFFFAOYSA-N
SMILES: C(O)(=O)COC1=CC=C(C=O)C=C1
CAS DataBase Reference: 22042-71-3(CAS DataBase Reference)
EPA Substance Registry System: Acetic acid, (4-formylphenoxy)- (22042-71-3)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0319
Product name: 4-Formylphenoxyacetic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 25g
Price: $178
Updated: 2021/12/16

TRC

Product number: F701503
Product name: 2-(4-Formylphenoxy)aceticAcid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Z1607
Product name: p-Formylphenoxyaceticacid
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: Z1607
Product name: p-Formylphenoxyaceticacid
Packaging: 5g
Price: $41
Updated: 2021/12/16

Apolloscientific

Product number: OR930525
Product name: 4-Formylphenoxyacetic Acid
Purity: 98%
Packaging: 5g
Price: $109
Updated: 2021/12/16

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4-Formylphenoxyacetic acid Chemical Properties,Usage,Production

Chemical Properties

BEIGE CRYSTALLINE POWDER

Uses

4-Formylphenoxyacetic acid is used as an organic chemical synthesis intermediate.

General Description

4-Formylphenoxyacetic acid is a formylphenoxyaliphatic acid that reacts with dimedone to form 1,8-dioxo-octahydroxanthenes. It participates in the synthesis of 4-substituted benzaldehyde derivatives and 4-carboxypheoxyacetic acid.

Synthesis

123-08-0

79-08-3

22042-71-3

The general procedure for the synthesis of 2-(4-formylphenoxy)acetic acid from p-hydroxybenzaldehyde and bromoacetic acid was as follows: potassium carbonate (24.9 g, 180.0 mmol) was added to a solution of 4-hydroxybenzaldehyde (10.0 g, 82.0 mmol) in acetone (150 mL) and the reaction mixture was stirred for 15 min at 40 °C. Subsequently, bromoacetic acid (12.0 g, 86.0 mmol) was added slowly in batches and the reaction mixture was heated to reflux for 18 hours. After completion of the reaction, the reaction mixture was cooled and diluted by adding water (200 mL). The reaction mixture was extracted with ethyl acetate (2 x 200 mL) and after combining the organic phases, the aqueous layer was adjusted to pH 2 with 6N hydrochloric acid. the aqueous layer was again extracted with ethyl acetate (2 x 400 mL), the organic phases were combined and washed with water (200 mL), dried with anhydrous sodium sulfate and finally concentrated under vacuum. The residue was ground with isohexane to afford the target compound 2-(4-formylphenoxy)acetic acid (13.5 g, 91% yield) as a creamy white solid.1H NMR (d6-DMSO) δ: 13.12 (br s, 1H), 9.87 (s, 1H), 7.88-7.85 (m, 2H), 7.12-7.10 (m, 2H). 4.83 (s, 2H).

References

[1] Patent: WO2015/86509, 2015, A1. Location in patent: Page/Page column 92; 93
[2] Main Group Metal Chemistry, 2015, vol. 38, # 5-6, p. 157 - 164
[3] Patent: WO2004/89945, 2004, A1. Location in patent: Page 8
[4] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 230 - 239

4-Formylphenoxyacetic acid Preparation Products And Raw materials

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4-Formylphenoxyacetic acid Suppliers

Americas 1 Belgium 2 China 98 Europe 1 Finland 1 France 2 Germany 8 India 9 Japan 2 Russia 1 Switzerland 3 United Kingdom 7 United States 22 Global 157

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View Lastest Price from 4-Formylphenoxyacetic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Formylphenoxyacetic acid 22042-71-3
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-19

Career Henan Chemical Co

Product: 2-(4-formylphenoxy)acetic acid 22042-71-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

22042-71-3, 4-Formylphenoxyacetic acidRelated Search:

4-Methoxybenzyl alcohol m-Anisyl alcohol Methyl methoxyacetate p-Anisaldehyde Phenoxyacetic acid (Trifluoromethoxy)benzene Anisole 4-Methoxyphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate 4-Methoxybenzoic acid Methoxyacetic acid Ascoric Acid 4-ACETYLPHENOXYACETIC ACID R(+)-IAA-94 Ethacrynic acid efloxate 4-CARBOXYPHENOXYACETIC ACID Phenylacetic acid

4-FORMYLPHENOXYACETIC ACID

4-Formyl-PAA

4-Formylphenoxyacetic acid,99%

4-Formylphenoxyacetic acid >=97.0% (T)

ASISCHEM R21550

AKOS AU36-M42

AKOS B004256

4-FORMYL-PAA LINKER

(4-formylphenoxy)-aceticaci

P-FORMYLPHENOXYACETIC ACID

4-FormylphenoxyaceticAcid&gt

Acetic acid, 2-(4-formylphenoxy)-

2-(4-formylphenoxy)aceticaci

4-Formylphenoxyacetic acid-98%

22042-71-3

CARBOXYLIC ACID

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