N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride

Product Name: N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
CAS No.: 194093-42-0
Chemical Name: N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
Synonyms: DDP733;Pumosetrag;MKC-733 >=98% (HPLC);Pumosetrag hydrochloride;PuMosetrag hydrochloride MKC-733;Pumosetrag Hydrochloride/MKC-733/DDP-733;7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride;N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
CBNumber: CB31260204
Molecular Formula: C15H18ClN3O2S
Formula Weight: 339.84
MOL File: 194093-42-0.mol

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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Property

storage temp.: 2-8°C
solubility: H2O: soluble25mg/mL, clear
form: powder
color: white to beige
optical activity: [α]/D -15 to -20°, c = 1 in H2O
Water Solubility: H2O: 25mg/mL, clear

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1038
Product name: MKC-733
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $304
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1038
Product name: MKC-733
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2022/05/15

ChemScene

Product number: CS-7917
Product name: PumosetragHydrochloride
Purity: 99.77%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-7917
Product name: PumosetragHydrochloride
Purity: 99.77%
Packaging: 10mg
Price: $204
Updated: 2021/12/16

ChemScene

Product number: CS-7917
Product name: PumosetragHydrochloride
Purity: 99.77%
Packaging: 25mg
Price: $468
Updated: 2021/12/16

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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Chemical Properties,Usage,Production

Uses

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Biological Activity

MKC-733 is a 5-HT3 specific agonist.

in vivo

Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors^[1]. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit^[2].

IC 50

5-HT₃ Receptor

References

[1] Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19. DOI:10.1159/000109984
[2] Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48. DOI:10.1046/j.1365-2036.2003.01797.x

N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Suppliers

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194093-42-0, N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochlorideRelated Search:

PRND QUINUCLIDINE

N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride

7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride

Pumosetrag hydrochloride

PuMosetrag hydrochloride MKC-733

DDP733

N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride

Pumosetrag

MKC-733 >=98% (HPLC)

Pumosetrag Hydrochloride/MKC-733/DDP-733

194093-42-0

C15H17N3O2SHCl

C15H18ClN3O2S