ChemicalBook > CAS DataBase List > N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride

N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride

Product Name
N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
CAS No.
194093-42-0
Chemical Name
N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
Synonyms
DDP733;Pumosetrag;MKC-733 >=98% (HPLC);Pumosetrag hydrochloride;PuMosetrag hydrochloride MKC-733;Pumosetrag Hydrochloride/MKC-733/DDP-733;7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride;N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
CBNumber
CB31260204
Molecular Formula
C15H18ClN3O2S
Formula Weight
339.84
MOL File
194093-42-0.mol
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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: soluble25mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -15 to -20°, c = 1 in H2O
Water Solubility 
H2O: 25mg/mL, clear
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1038
Product name
MKC-733
Purity
≥98% (HPLC)
Packaging
25mg
Price
$304
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1038
Product name
MKC-733
Purity
≥98% (HPLC)
Packaging
5mg
Price
$129
Updated
2022/05/15
ChemScene
Product number
CS-7917
Product name
PumosetragHydrochloride
Purity
99.77%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-7917
Product name
PumosetragHydrochloride
Purity
99.77%
Packaging
10mg
Price
$204
Updated
2021/12/16
ChemScene
Product number
CS-7917
Product name
PumosetragHydrochloride
Purity
99.77%
Packaging
25mg
Price
$468
Updated
2021/12/16
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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Chemical Properties,Usage,Production

Uses

Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Biological Activity

MKC-733 is a 5-HT3 specific agonist.

in vivo

Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1]. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit[2].

IC 50

5-HT3 Receptor

References

[1] Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19. DOI:10.1159/000109984
[2] Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48. DOI:10.1046/j.1365-2036.2003.01797.x

N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride Suppliers

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194093-42-0, N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochlorideRelated Search:

PRND QUINUCLIDINE

  • N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
  • 7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride
  • Pumosetrag hydrochloride
  • PuMosetrag hydrochloride MKC-733
  • DDP733
  • N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride
  • Pumosetrag
  • MKC-733 >=98% (HPLC)
  • Pumosetrag Hydrochloride/MKC-733/DDP-733
  • 194093-42-0
  • C15H17N3O2SHCl
  • C15H18ClN3O2S