ChemicalBook > CAS DataBase List > curvularin

curvularin

Product Name
curvularin
CAS No.
10140-70-2
Chemical Name
curvularin
Synonyms
curvularin;(-)-Curvularin;(S)-Curvularin;S-Curvularin, NSC 166071;2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
CBNumber
CB31341734
Molecular Formula
C16H20O5
Formula Weight
292.33
MOL File
10140-70-2.mol
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curvularin Property

Melting point:
206-206.5°
alpha 
D18 -36.3° (c = 3.8 in ethanol)
Boiling point:
557.0±29.0 °C(Predicted)
Density 
1.200±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble1mg/mL
form 
powder
pka
7.58±0.40(Predicted)
color 
Off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
29419000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0772
Product name
Curvularin
Purity
from
Packaging
5mg
Price
$205.6
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0772
Product name
Curvularin
Purity
from
Packaging
1mg
Price
$109
Updated
2022/05/15
Cayman Chemical
Product number
21758
Product name
Curvularin
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
21758
Product name
Curvularin
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
TRC
Product number
C844503
Product name
Curvularin
Packaging
1mg
Price
$50
Updated
2021/12/16
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curvularin Chemical Properties,Usage,Production

Uses

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

Uses

Curvularin is a potent antifungal and mycotoxin that also inhibits NO production.

storage

+4°C

curvularin Preparation Products And Raw materials

Raw materials

Preparation Products

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curvularin Suppliers

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10140-70-2, curvularinRelated Search:

NYSTATIN A1 TRIHYDRATE curvularin 4-Hexanoylresorcinol Methyl 3,5-dihydroxyphenylacetate

  • curvularin
  • 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
  • S-Curvularin, NSC 166071
  • (S)-Curvularin
  • (-)-Curvularin
  • 10140-70-2
  • Antibiotic