curvularin Property

Melting point:

206-206.5°

alpha 

D18 -36.3° (c = 3.8 in ethanol)

Boiling point:

557.0±29.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: soluble1mg/mL

form 

powder

pka

7.58±0.40(Predicted)

color 

Off-white

Safety

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HS Code 

29419000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

curvularin Chemical Properties,Usage,Production

Uses

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

Uses

Curvularin is a potent antifungal and mycotoxin that also inhibits NO production.

storage

+4°C