curvularin

Product Name: curvularin
CAS No.: 10140-70-2
Chemical Name: curvularin
Synonyms: curvularin;(-)-Curvularin;(S)-Curvularin;S-Curvularin, NSC 166071;2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
CBNumber: CB31341734
Molecular Formula: C16H20O5
Formula Weight: 292.33
MOL File: 10140-70-2.mol

More

Less

curvularin Property

Melting point:: 206-206.5°
alpha: D18 -36.3° (c = 3.8 in ethanol)
Boiling point:: 557.0±29.0 °C(Predicted)
Density: 1.200±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble1mg/mL
form: powder
pka: 7.58±0.40(Predicted)
color: Off-white

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 29419000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0772
Product name: Curvularin
Purity: from
Packaging: 5mg
Price: $205.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0772
Product name: Curvularin
Purity: from
Packaging: 1mg
Price: $109
Updated: 2022/05/15

Cayman Chemical

Product number: 21758
Product name: Curvularin
Purity: ≥98%
Packaging: 1mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 21758
Product name: Curvularin
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

TRC

Product number: C844503
Product name: Curvularin
Packaging: 1mg
Price: $50
Updated: 2021/12/16

More

Less

curvularin Chemical Properties,Usage,Production

Uses

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

Uses

Curvularin is a potent antifungal and mycotoxin that also inhibits NO production.

storage

+4°C

curvularin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

curvularin Suppliers

China 46 India 1 United Kingdom 2 United States 9 Global 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

10140-70-2, curvularinRelated Search:

NYSTATIN A1 TRIHYDRATE curvularin 4-Hexanoylresorcinol Methyl 3,5-dihydroxyphenylacetate

curvularin

2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-

S-Curvularin, NSC 166071

(S)-Curvularin

(-)-Curvularin

10140-70-2

Antibiotic