2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE

Product Name: 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE
CAS No.: 95453-58-0
Chemical Name: 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE
Synonyms: 2-Chloro-5-formylthiazole;2-Chloro-5-formyl-1,3-thiazole;2-chlorothiazole-5-carbaldehyde;2-Chloro-5-thiazolecarbaldehyde;2-Chlorothiazole-5-carboxaldehyde;2-chloro-5-thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde, 2-chloro-;2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE;2-Chloro-1,3-thiazole-5-carboxaldehyde;5-Thiazolecarboxaldehyde, 2-chloro- (9CI)
CBNumber: CB3138166
Molecular Formula: C4H2ClNOS
Formula Weight: 147.58
MOL File: 95453-58-0.mol

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2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE Property

Melting point:: 85-88°C
Boiling point:: 278.6±32.0 °C(Predicted)
Density: 1.541±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: -0.94±0.10(Predicted)
color: White to orange
Sensitive: Air Sensitive
InChI: InChI=1S/C4H2ClNOS/c5-4-6-1-3(2-7)8-4/h1-2H
InChIKey: PKCBQQXHFIDIIG-UHFFFAOYSA-N
SMILES: S1C(C=O)=CN=C1Cl

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Safety

Risk Statements: 43
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00395
Product name: 2-Chlorothiazole-5-carboxaldehyde
Packaging: 1g
Price: $356
Updated: 2025/07/31

TRC

Product number: C411470
Product name: 2-Chloro-1,3-thiazole-5-carbaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 042709
Product name: 2-Chloro-1,3-thiazole-5-carbaldehyde
Purity: 95+%
Packaging: 5g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC54374
Product name: 2-Chloro-5-formylthiazole
Packaging: 2g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: X1275
Product name: 2-Chlorothiazole-5-carbaldehyde
Packaging: 10g
Price: $167
Updated: 2021/12/16

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2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

3034-52-4

109-94-4

95453-58-0

General procedure: n-Butyl lithium (n-BuLi, 320 mL, 0.8 mol) was slowly added dropwise to a stirred solution of anhydrous THF (1000 mL) of 2-chlorothiazole (80 g) at -78 °C for 1 hour. Maintaining the reaction temperature at -78 °C, ethyl formate (74 g) was slowly added dropwise to the above solution, and the reaction continued to be stirred for 1 hour after the dropwise addition was completed. Saturated ammonium chloride (NH4Cl) solution was added to the reaction mixture and stirred for 30 minutes. Subsequently, the reaction mixture was diluted with ethyl acetate. The aqueous phase was separated and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from hexane/ethyl acetate mixed solvent to give 2-chloro-1,3-thiazole-5-carbaldehyde (72 g, yield: 73%). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.96 (s, 1H), 8.21 (s, 1H).

References

[1] Patent: WO2016/55431, 2016, A1. Location in patent: Page/Page column 75

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE Suppliers

Belgium 1 China 119 Europe 1 Germany 2 India 1 United Kingdom 3 United States 19 Global 146

Xi'an Yutebang New Material Technology Co., Ltd.

Tel: 029-84536388 18717328141
Fax: 029-84536389
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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ProdList: 96815
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Alfa Aesar

Tel: 400-6106006
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Email: saleschina@alfa-asia.com
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Wuhan Chemwish Technology Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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ZEROSCHEM.CO.,LTD.

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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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View Lastest Price from 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Chloro-1,3-thiazole-5-carbaldehyde 95453-58-0
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Henan Aochuang Chemical Co.,Ltd.

Product: 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE 95453-58-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE 95453-58-0
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

95453-58-0, 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDERelated Search:

Paraformaldehyde METHYL 2-CHLORO-4-THIAZOLECARBOXYLATE 2-CHLORO-1,3-THIAZOLE-5-CARBOXYLIC ACID 5-Thiazolecarboxylic acid, 2,4-dichloro- ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE 2,4-Dichloro-5-thiazolecarboxaldehyde 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE tert-butyl 2-chloro-1,3-thiazole-5-carboxylate 2-CHLORO-4-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLIC ACID 5-Thiazolecarbonyl chloride, 2-chloro- (9CI) Methyl2,4-dichlorothiazole-5-carboxylate ETHYL 2-CHLORO-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLATE ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Methyl4-bromo-2-chlorothiazole-5-carboxylate 2-CHLORO-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE OXIME 4-CHLORO-2-PHENYLAMINO-THIAZOLE-5-CARBALDEHYDE 2-amino-4-chloro-1,3-thiazole-5-carbaldehyde

2-Chloro-1,3-Thiazole-5-Carbaldehyde(WX624029)

2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE

5-Thiazolecarboxaldehyde, 2-chloro- (9CI)

2-Chloro-1,3-thiazole-5-carboxaldehyde 97%

2-Chloro-1,3-thiazole-5-carboxaldehyde

2-Chloro-5-formylthiazole

2-Chloro-5-formyl-1,3-thiazole

2-Chlorothiazole-5-carboxaldehyde

2-chlorothiazole-5-carbaldehyde

2-chloro-5-thiazolecarboxaldehyde

5-Thiazolecarboxaldehyde, 2-chloro-

99% purity 2-CHLORO-1,3-THIAZOLE-5-CARBALDEHYDE

2-Chloro-5-thiazolecarbaldehyde

95453-58-0

ALDEHYDE

Building Blocks

Thiazole