ChemicalBook > CAS DataBase List > 4-chloro-6,7-dimethoxy-2-methylquinazoline

4-chloro-6,7-dimethoxy-2-methylquinazoline

Product Name
4-chloro-6,7-dimethoxy-2-methylquinazoline
CAS No.
50377-49-6
Chemical Name
4-chloro-6,7-dimethoxy-2-methylquinazoline
Synonyms
2-Methyl-4-chloro-6,7-dimethoxyquinoline;4-chloro-6,7-dimethoxy-2-methylquinazoline;4-Chloro-2-methyl-6,7-dimethoxyquinazoline;Quinazoline, 4-chloro-6,7-dimethoxy-2-methyl-
CBNumber
CB31465085
Molecular Formula
C11H11ClN2O2
Formula Weight
238.67
MOL File
50377-49-6.mol
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4-chloro-6,7-dimethoxy-2-methylquinazoline Property

Boiling point:
287℃
Density 
1.281
Flash point:
127℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Light yellow to brown Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
6918AB
Product name
4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging
250mg
Price
$196
Updated
2021/12/16
AK Scientific
Product number
6918AB
Product name
4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging
1g
Price
$415
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
1G
Price
$794.36
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
5G
Price
$1388.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
10G
Price
$2055.62
Updated
2021/12/16
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4-chloro-6,7-dimethoxy-2-methylquinazoline Chemical Properties,Usage,Production

Synthesis

35241-23-7

50377-49-6

Step b Synthesis of 4-chloro-6,7-dimethoxy-2-methylquinazoline: 6,7-dimethoxy-2-methylquinazolin-4(3H)-one (1.0 g) was mixed with phosphorus trichloride (20 mL) and heated to reflux for 3 hours. After the reaction was completed, the mixture was cooled to room temperature, slowly poured into ice water and stirred for 10 min. The aqueous phase was extracted with chloroform (3 x 100 mL), the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give the yellow solid product 4-chloro-6,7-dimethoxy-2-methylquinazoline (1.0 g, 92% yield) with a melting point of 182-184 °C. 1H NMR (400 MHz, CDCl3): δ 7.36 (1H, s), 7.30 (1H, s), 4.06 (6H, s), 2.81 (3H, s); LC-MS (positive ion mode): m/z 239, 241 [M+H]+.

References

[1] Patent: US2013/266563, 2013, A1. Location in patent: Paragraph 0327
[2] Synthesis, 2004, # 3, p. 429 - 435
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] ChemMedChem, 2014, vol. 9, # 7, p. 1476 - 1487

4-chloro-6,7-dimethoxy-2-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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50377-49-6, 4-chloro-6,7-dimethoxy-2-methylquinazolineRelated Search:

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  • 4-chloro-6,7-dimethoxy-2-methylquinazoline
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  • 4-Chloro-2-methyl-6,7-dimethoxyquinazoline
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  • 50377-49-6