ChemicalBook > CAS DataBase List > 4-chloro-6,7-dimethoxy-2-methylquinazoline

4-chloro-6,7-dimethoxy-2-methylquinazoline

Product Name
4-chloro-6,7-dimethoxy-2-methylquinazoline
CAS No.
50377-49-6
Chemical Name
4-chloro-6,7-dimethoxy-2-methylquinazoline
Synonyms
2-Methyl-4-chloro-6,7-dimethoxyquinoline;4-chloro-6,7-dimethoxy-2-methylquinazoline;4-Chloro-2-methyl-6,7-dimethoxyquinazoline;Quinazoline, 4-chloro-6,7-dimethoxy-2-methyl-
CBNumber
CB31465085
Molecular Formula
C11H11ClN2O2
Formula Weight
238.67
MOL File
50377-49-6.mol
More
Less

4-chloro-6,7-dimethoxy-2-methylquinazoline Property

Boiling point:
287℃
Density 
1.281
Flash point:
127℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Light yellow to brown Solid
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

AK Scientific
Product number
6918AB
Product name
4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging
250mg
Price
$196
Updated
2021/12/16
AK Scientific
Product number
6918AB
Product name
4-Chloro-6,7-dimethoxy-2-methylquinazoline
Packaging
1g
Price
$415
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
1G
Price
$794.36
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
5G
Price
$1388.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050043
Product name
4-CHLORO-6,7-DIMETHOXY-2-METHYLQUINAZOLINE
Purity
95.00%
Packaging
10G
Price
$2055.62
Updated
2021/12/16
More
Less

4-chloro-6,7-dimethoxy-2-methylquinazoline Chemical Properties,Usage,Production

Synthesis

35241-23-7

50377-49-6

Step b Synthesis of 4-chloro-6,7-dimethoxy-2-methylquinazoline: 6,7-dimethoxy-2-methylquinazolin-4(3H)-one (1.0 g) was mixed with phosphorus trichloride (20 mL) and heated to reflux for 3 hours. After the reaction was completed, the mixture was cooled to room temperature, slowly poured into ice water and stirred for 10 min. The aqueous phase was extracted with chloroform (3 x 100 mL), the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give the yellow solid product 4-chloro-6,7-dimethoxy-2-methylquinazoline (1.0 g, 92% yield) with a melting point of 182-184 °C. 1H NMR (400 MHz, CDCl3): δ 7.36 (1H, s), 7.30 (1H, s), 4.06 (6H, s), 2.81 (3H, s); LC-MS (positive ion mode): m/z 239, 241 [M+H]+.

References

[1] Patent: US2013/266563, 2013, A1. Location in patent: Paragraph 0327
[2] Synthesis, 2004, # 3, p. 429 - 435
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] ChemMedChem, 2014, vol. 9, # 7, p. 1476 - 1487

4-chloro-6,7-dimethoxy-2-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-chloro-6,7-dimethoxy-2-methylquinazoline Suppliers

China 47 Germany 1 India 1 United States 10 Global 59
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
998
Advantage
56
Chiba Pharmaceutical Science and technology Co, Ltd.
Tel
0531-81313138 13066006660
Fax
QQ: 3366077777
Email
chibapharm@foxmail.com
Country
China
ProdList
3991
Advantage
55
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
ShangHai AmK Pharmaceutical Technology Co., Ltd.
Tel
微信 17321281695 18019252918
Fax
17321281695
Email
sale@amkchem.com
Country
China
ProdList
15136
Advantage
55
Shanghai RenYue Chemical Technology Co., Ltd.
Tel
021-62219190; 18321139117
Email
316441092@qq.com
Country
China
ProdList
2908
Advantage
55
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Suzhou JingTong Pharmaceutical Co., Ltd.
Tel
13675155016
Fax
18912765016
Email
tongtf110@sina.com
Country
China
ProdList
963
Advantage
55
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
Sichuan BaiPeng Biotechnology Co., Ltd.
Tel
028-65791793 18140026355
Fax
QQ568470422
Email
568470422@qq.com
Country
China
ProdList
9997
Advantage
58
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
15026866316
Email
180642609@qq.com
Country
China
ProdList
4967
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26028
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Krain Pharmaceutical Technology CO.,Ltd
Tel
18252089365
Email
Krain_kerun@163.com
Country
China
ProdList
2507
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
ET-market@chemextension.com
Country
China
ProdList
4673
Advantage
58
Hubei Co-prosperity Medicine Technonlogy Co., Ltd
Tel
2383948258 19172820304
Email
2383948258@qq.com
Country
China
ProdList
12987
Advantage
58
SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Email
guoxin@chembiobanksh.com
Country
China
ProdList
2666
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
7048
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Shandong Mingde Biotechnology Co., Ltd
Tel
15553348166
Email
m15553348166@163.com
Country
China
ProdList
9967
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188 13327728092
Email
sales@pharmablock.com
Country
China
ProdList
10000
Advantage
58
Changzhou Qianai Biotechnology Co., Ltd
Tel
051915240519135 13961152745
Email
yudiguimo@126.COM
Country
China
ProdList
10000
Advantage
58
xinguokeji
Tel
13120711461
Email
363372932@qq.com
Country
China
ProdList
498
Advantage
58
DAYANG CHEM (HANGZHOU) CO.,LTD
Tel
+86-88938639 +86-17705817739
Email
info@dycnchem.com
Country
China
ProdList
53899
Advantage
58
Qingdao Dexin Chemical Co., Ltd
Tel
+86-15553333686
Email
15553333686@qq.com
Country
China
ProdList
3113
Advantage
58
Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel
+8613720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5221
Advantage
58
Sichuan Biosynce Pharmatech Co., Ltd.
Tel
+8619950309693
Email
diane@biosynce.com
Country
China
ProdList
4871
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Golden Pharma Co., Limited
Tel
+undefined18958062155
Email
sales@zjgoldpharm.com
Country
China
ProdList
5899
Advantage
58
Guangzhou Weike Biotechnology Co., Ltd.
Tel
15902098758
Country
CHINA
ProdList
133
Advantage
58
Hangzhou Bio-and Chemicals Co., Ltd
Tel
--
Fax
--
Email
sales@baokaichem.com
Country
China
ProdList
49
Advantage
60

50377-49-6, 4-chloro-6,7-dimethoxy-2-methylquinazolineRelated Search:

4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 4-CHLORO-6-METHYLTHIOPYRIMIDINE 4-CHLORO-6-CYANOQUINOLINE 4-CHLORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-Chloro-6-hydrazinopyrimidine 4-Chloro-6-methylquinoline ETHYL 4-CHLORO-6-METHYL-3-QUINOLINECARBOXYLATE 4-chloro-6-methylquinoline-3-carbonitrile ethyl 4-chloro-6-methoxy-quinoline-3-carboxylate 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 4-chloro-6-methoxy-2-methylpyrimidin-5-amine 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE 4-CHLORO-6,7-DIMETHYLENEDIOXYQUINAZOLINE (6-Chloro-pyrimidin-4-yl)-dimethyl-amine 4-CHLORO-6-NITROQUINAZOLINE ETHYL 4-CHLORO-6-FLUORO-3-QUINOLINECARBOXYLATE 4-CHLORO-6-FLUOROQUINAZOLINE 4-CHLORO-6-(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDINE

  • 4-chloro-6,7-dimethoxy-2-methylquinazoline
  • 2-Methyl-4-chloro-6,7-dimethoxyquinoline
  • 4-Chloro-2-methyl-6,7-dimethoxyquinazoline
  • Quinazoline, 4-chloro-6,7-dimethoxy-2-methyl-
  • 50377-49-6