ChemicalBook > CAS DataBase List > 5,7-dichlorothiazolo[5,4-d]pyrimidine
5,7-dichlorothiazolo[5,4-d]pyrimidine
- Product Name
- 5,7-dichlorothiazolo[5,4-d]pyrimidine
- CAS No.
- 13479-88-4
- Chemical Name
- 5,7-dichlorothiazolo[5,4-d]pyrimidine
- Synonyms
- 5,7-dichlorothiazolo[5,4-d]pyrimidine;Thiazolo[5,4-d]pyrimidine, 5,7-dichloro-;5,7-dichloro-[1,3]thiazolo[5,4-d]pyriMidine
- CBNumber
- CB31483436
- Molecular Formula
- C5HCl2N3S
- Formula Weight
- 206.05
- MOL File
- 13479-88-4.mol
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5,7-dichlorothiazolo[5,4-d]pyrimidine Property
- Melting point:
- 148.5-149.5 °C
- Boiling point:
- 281.2±22.0 °C(Predicted)
- Density
- 1.767±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 2 mg/ml,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
- form
- A solid
- pka
- -2.68±0.50(Predicted)
- color
- Light yellow to brown
- InChI
- InChI=1S/C5HCl2N3S/c6-3-2-4(11-1-8-2)10-5(7)9-3/h1H
- InChIKey
- XYBGDWLYHQAUQM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2N=CSC2=N1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- D436463
- Product name
- 5,7-Dichlorothiazolo[5,4-d]pyrimidine
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD142325
- Product name
- 5,7-Dichlorothiazolo[5,4-d]pyrimidine
- Packaging
- 50mg
- Price
- $82
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD142325
- Product name
- 5,7-Dichlorothiazolo[5,4-d]pyrimidine
- Packaging
- 100mg
- Price
- $142
- Updated
- 2021/12/16
AK Scientific
- Product number
- X9888
- Product name
- 5,7-Dichlorothiazolo[5,4-d]pyrimidine
- Packaging
- 250mg
- Price
- $262
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD142325
- Product name
- 5,7-Dichlorothiazolo[5,4-d]pyrimidine
- Packaging
- 250mg
- Price
- $282.5
- Updated
- 2021/12/16
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5,7-dichlorothiazolo[5,4-d]pyrimidine Chemical Properties,Usage,Production
Uses
5,7-Dichlorothiazolo[5,4-d]pyrimidine was used in studies to prepare Kinase inhibitors.
Synthesis
5082-82-6
13479-88-4
The general procedure for the synthesis of 5,7-dichlorothiazolo[5,4-d]pyrimidine using thiazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione as starting material was as follows: a 10 mL round bottom flask was charged with intermediate 45.2 (100 mg, 0.59 mmol, 1.00 equiv.), N,N-diisopropylethylamine (DIEA, 0.5 mL) and phosphorus oxychloride (POCl3, 2 mL). The reaction mixture was stirred at 100 °C for 12 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography to afford intermediate 45.3 (100 mg, 82% yield) as a yellow oil.
References
[1] Heterocycles, 2012, vol. 85, # 7, p. 1721 - 1726
[2] Patent: WO2015/48281, 2015, A1. Location in patent: Paragraph 00472; 00475
[3] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 168; 169
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 3862
5,7-dichlorothiazolo[5,4-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,7-dichlorothiazolo[5,4-d]pyrimidine manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5,7-dichlorothiazolo[5,4-d]pyriMidine 13479-88-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
Career Henan Chemical Co
- Product
- 5,7-dichlorothiazolo[5,4-d]pyrimidine 13479-88-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 97%-99%
- Supply Ability
- as request
- Release date
- 2018-12-23