2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER
- Product Name
- 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER
- CAS No.
- 391-93-5
- Chemical Name
- 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER
- Synonyms
- UKRORGSYN-BB BBV-199988;2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER;Benzoic acid, 2-aMino-5-fluoro-, ethyl ester
- CBNumber
- CB31484286
- Molecular Formula
- C9H10FNO2
- Formula Weight
- 183.18
- MOL File
- 391-93-5.mol
2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER Property
- Boiling point:
- 280.2±25.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.09±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2922498590
N-Bromosuccinimide Price
- Product number
- 4725CS
- Product name
- Ethyl2-amino-5-fluorobenzoate
- Packaging
- 1g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 4725CS
- Product name
- Ethyl2-amino-5-fluorobenzoate
- Packaging
- 5g
- Price
- $431
- Updated
- 2021/12/16
- Product number
- HCH0101126
- Product name
- ETHYL 2-AMINO-5-FLUOROBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.78
- Updated
- 2021/12/16
- Product number
- 391935
- Product name
- Ethyl2-amino-5-fluorobenzoate
- Packaging
- 500mg
- Price
- $847.6
- Updated
- 2021/12/16
- Product number
- CM252682
- Product name
- Ethyl2-amino-5-fluorobenzoate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $916
- Updated
- 2021/12/16
2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
446-08-2
391-93-5
A. Synthesis of ethyl 2-amino-5-fluorobenzoate 2-Amino-5-fluorobenzoic acid (1.0 g, 6.4 mmol) was dissolved in a mixed solvent of ethanol (15 mL) and toluene (10 mL). Several drops of concentrated sulfuric acid (H2SO4) were added as a catalyst. A Dean-Stark splitter was installed and the reaction mixture was refluxed overnight. After completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The product was purified by silica gel column chromatography (4×15 cm), and the target product was obtained in 50% yield by sequential gradient elution with chloroform/methanol (98:2, v/v, 500 mL) and (95:5, v/v, 500 mL) as eluents. Mass spectrum (ES+): m/z 184.0 ([M+H]+); 1H NMR (CDCl3) δ 7.55 (d, 1H, ArH), 7.03 (m, 1H, ArH), 6.61 (dd, 1H, ArH), 5.6 (bs, 2H, NH2), 4.33 (q, 2H, CH2), 1.40 (t, 3H, CH3).
References
[1] Patent: US2003/69271, 2003, A1
2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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