PROPERICYAZINE
- Product Name
- PROPERICYAZINE
- CAS No.
- 2622-26-6
- Chemical Name
- PROPERICYAZINE
- Synonyms
- ic6002;rp8908;wh7508;6909rp;Aolept;IC 6002;RP 8908;RP 8909;WH 7508;6909 RP
- CBNumber
- CB3162774
- Molecular Formula
- C21H23N3OS
- Formula Weight
- 365.49
- MOL File
- 2622-26-6.mol
PROPERICYAZINE Property
- Melting point:
- 116-117°
- Boiling point:
- 593.4±50.0 °C(Predicted)
- Density
- 1.1198 (rough estimate)
- refractive index
- 1.6740 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.87±0.20(Predicted)
- color
- Light Yellow to Yellow
- Water Solubility
- 38.01mg/L(37 ºC)
- CAS DataBase Reference
- 2622-26-6
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 26-36
- RTECS
- SN7175000
- Toxicity
- LD50 orally in rats: 395 mg/kg (Schafer)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P287360
- Product name
- Pericyazine
- Packaging
- 25mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- P287360
- Product name
- Pericyazine
- Packaging
- 250mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- API0003549
- Product name
- PROPERICYAZINE
- Purity
- 95.00%
- Packaging
- 2G
- Price
- $2035
- Updated
- 2021/12/16
- Product number
- CS-0002963
- Product name
- Pericyazine
- Purity
- 99.83%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0002963
- Product name
- Pericyazine
- Purity
- 99.83%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
PROPERICYAZINE Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Originator
Aolept, Bayer Vital
Uses
Spectrophotometric reagent for palladium and ruthenium.
Uses
Psychotherapeutic phenothiazine. Antipsychotic.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Manufacturing Process
2-Cyano-10-(3-methanesulfonyloxypropyl)phenthiazine and 4hydroxypiperidine in toluene were heated under reflux with stirring. The reaction mixture was allowed to cool and water was added. The resulting toluene solution layer was decanted and washed twice with water. The toluene solution was then stirred with 5% hydrochloric acid. The hydrochloride of the desired phenthiazine base precipitated in gummy condition in the aqueous layer. This was decanted and treated with sodium hydroxide (density 1.33). It was then extracted three times with ethyl acetate. The extracts were dried over sodium sulfate, filtered and concentrated in vacuum. A resinous product was obtained. This product was dissolved in a mixture of benzene and cyclohexane and chromatographed on a column containing alumina. The chromatographed product was eluted successively with mixtures of benzene and cyclohexane and then with benzene and finally with a mixture of benzene and ethyl acetate. The eluates were evaporated to yield a crude product. This product was recrystallised from aqueous ethanol (40% water) and yielded 2cyano-10-[3-(4-hydroxy-1-piperidyl)propyl]phenthiazine as white crystals.
Therapeutic Function
Neuroleptic
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Used as an antipsychotic agent. When heated to decomposition it emits very toxic fumes of CN-, NOx, and SOx. See also NITRILES.
Purification Methods
It recrystallises from a saturated solution in cyclohexane. It is antipsychotic and is a sensitive reagent for Pd, Va, Ru, Rh and Au. [Gowda et al. Anal Chem 55 1816 1983, Anal Chim Acta 154 347 1983, Beilstein 27 III/IV 4110.]
PROPERICYAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
PROPERICYAZINE Suppliers
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